CD4+CD25+ regulatory T cells

Crelfin NK, Garcia RV, Levings MK Altered activation of AKT is required for the suppressive function of human CD4+CD25+ T regulatory cells. 

Ryan KR, Lawson CA, Lorenzi AR, Arkwright PD, Isaacs JD, Lihc D CD4+CD25+ T-regulatory cells are decreased in patients with autoimmune polyendocrinopathy candidiasis ectodermal dystrophy. J Allergy Clin Immunol 2005 116 1158-1159. 

Antony PA. Restifo NP CD4+CD25 + T regulatory cells, immunotherapy of cancer, and interleukin-2. J Immuno-ther 2005 28 120-128. 

Ramsdell F An essential role for Scurfin in CD4+CD25+ T regulatory cells. Nat Immunol 2003 4 337-342. 

Battaglia A, Ferrandina G, Buzzonetti A, Malinconico P, Legge F, Salutari V, et al Lymphocyte populations in human lymph nodes. Alterations in CD4+ CD25+ T regulatory cell phenotype and T-cell receptor Vp repertoire. Immunology 2003 110 304-312. 

Hall BM, Chen J, Robinson C, Xy H, et al. 2002. Therapy with mab to CD25 blocks function of CD4+CD25+ T regulatory cells which maintain transplantation tolerance. Nephrology. 7 A111-A111. 

D. Mathis, C. Benoist, CD4+CD25+ T regulatory cells dependent on ICOS promote regulation of effector cells in the prediabetic lesion,/. Exp. Med. 2004, 199, 1479-1489. 

Chen X, Winkler Piekett RT, Carbonecci NH et al. Pertussis toxin as an adjuvant suppresses the number and function of CD4+CD25+ T regulatory cells. Eur J Immunol 2006 36(3) 671-680. 

Lewkowicz P. Lewkowicz N, Sasiak A, Tchorzewski H Lipopolysaccharide-activated CD4-I-CD25+ T regulatory cells inhibit neutrophil function and promote their apoptosis and death. 

GETNET D, GROSSO IF, GOLDBERG MV, HARRIS TJ, YEN HR, BRUNO TC, DURHAM NM, HIPKISS EL, PYLE KJ, WADA s, PAN F, PARDOLL DM, DRAKE CG (2010), A role for the transcription factor Helios in human CD4(+)CD25(-t) regulatory T cells . Mol Immunol, 47,1595-600. 

Francis JN, Till SJ, Durham SR Induction of 1L-10+CD4+CD25+ T cells by grass pollen immunotherapy. J Allergy Clin Immunol 2003 111 1255-1261. Jutel M, Akdis M, Budak F, Aebischer-Casaulta C. Wrzyszcz M, Blaser K, Akdis CA lL-10 and TGF-P cooperate in the regulatory T cell response to mucosal allergens in normal immunity and specific immunotherapy. Eur J Immunol 2003 33 1205-1214. 

Fontenot JD, Gavin MA, Rudensky AY Foxp3 programs the development and function of CD4+CD25 4- regulatory T cells. Nat Immunol 2003 4 330-336. 

Pandiyan P, Zheng L, Ishihara S, Reed J, Lenardo MJ CD4+CD25+Foxp3+ regulatory T cells induce cytokine deprivation-mediated apoptosis of effector CD4+ T cells. Nat Immunol 2007 8 1353-1362. 

Battaglia M, Stabilini A, Roncarolo MG Rapamycin selectively expands CD4+CD25 + FoxP3+ regulatory T cells. Blood 2005 105 4743-4748. 

Zambricki EA, Kambham N, Beilhack A, Loh J, Hou JZ, Negrin RS Differential impact of mTOR inhibition on CD4+CD25+Foxp3+ regulatory T cells as compared to conventional CD4+ Tcells. Blood 2008 111 453-462. 

Balandina A, Lecart S, Dartevelle P, Saoudi A, Berrih-Aknin S Functional defect of regulatory CD4+CD25+T cells in the thymus of patients with autoimmune myasthenia gravis. Blood 2005 105 735-741. 

Kearley J, Barker JE, Robinson DS, Lloyd CM Resolution of airway inflammation and hyperreactivity after in vivo transfer of CD4+CD25-I- regulatory T cells is interleukin-10 dependent. J Exp Med 2005 202 1539-1547. 

Levings MK, Sangregorio R, Roncarolo MG Human CD25+CD4+ T regulatory cells suppress naive and memory T cell proliferation and can be expanded in vitro without loss of function. J Exp Med 2001 193 1295-1302. 

CTLA-4 is constitutively expressed on Treg cells its deficiency is associated with fatal autoimmune proliferative disease, and inhibition of CTLA-4 by specific antibodies results in the development of autoimmune disease. Its polymorphism has a role in the development of autoimmune diseases including diabetes, Addison s disease and thyroid disease. Regulatory cells are involved in the development of disease resulting from antagonisms of CTLA-4, which may be the result of depletion of Treg cells by antibodies to CTLA-4. The activation of CD4+CD25 T cells as a... 

Shevach EM, DiPaolo RA, Anderson J, Zhao DM. 2006. The lifestyle of naturally occurring CD4+CD25+Foxp3+ regulatory T cells. Immunol Rev. 212 60-73. 

Levings, M. K., Sangregorio, R., Sartirana, C. et al. 2002. Human CD25+ CD4 suppressor cells clones produce transforming growth factor (3, but not interleukin 10, and are distinct from type 1 T regulatory cells. J Exp Med 196 1335-1336. 

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