Defective functioning

Type 2 diabetes is a heterogeneous and progressive endocrine disorder associated with insulin resistance (impaired insulin action) and defective function of the insulin-secreting (3-cells in the pancreatic islets of Langerhans. These endocrine disorders give rise to widespread metabolic disturbances epitomised by hyperglycaemia. The present classes of antidiabetic agents other than insulin act to either increase insulin secretion, improve insulin action, slow the rate of intestinal... 

Information obtained sp2/sp3 level (i.e. defect), functional groups, dopants, chirality. 

Hartnup disorder Is a rare condition caused by impaired resorption of neutral amino acids (especially tryptophan, alanine, threonine, glutamine, and histidine) In the renal tubules and malabsorption In the Intestine, resulting from mutations that lead to defective function of a neutral amino acid transporter. 

For small nonpolar species such as H2 and N2 the dominant interaction between the Rydberg electron and the nuclear vibrational and rotational motion occurs within a small radius around the ionic core, which is traversed in a fraction of a femtosecond. This short encounter justifies the sudden treatment of vibration and rotation in MQDT theory, while also permitting Bom-Oppenheimer estimates of the necessary quantum defect functions. It is also central to the n-3 scaling law because the core transit time is almost energy independent, while the Rydberg orbit time increases as n3. 

Nakatsu F, Okada M, Mori F, Kumazawa N, Iwasa H, et al. 2004. Defective function of GABA-containing synaptic vesicles in mice lacking the AP-3B clathrin adaptor. J Cell Biol 167 293-302. 

The autopsy confirmed the diagnoses and showed acid-fast bacilli in the adventitia of the basilar artery the paralysis of the oculomotor nerve was caused by the brain lesion. Defective function of macrophages was suggested as the possible cause of the underlying immunological abnormality (81). 

Hughes NC, Janezic SA, McQueen KL, Jewett MAS, Castranio T, Bell DA, et al. Identification and characterization of variant alleles of human acetyltransferase NATl with defective function using... 

In addition to these factors, any defect in absorption of any of the intermediate metabolites of the urea cycle, or an excessive urinary excretion of one of them, may result in a defective functioning of the cycle. Therefore the levels of these individual amino acids as well as of all the amino acids is important. Low levels of the plasma amino acids may result from a diet grossly deficient in protein, or from malabsorption in such conditions as celiac disease. 

In NPC mouse hepatocytes, a lipid imbalance was found, which increases lipid ordering in the plasma membrane, alters the properties of lipid rafts, and leads to defective function of the raft-associated plasma membrane insulin receptor (Vainio et al. 2005). This mechanism may participate in the pathogenesis of NPC disease and contribute to insulin resistance (Fonseca 2007) in other disorders of lipid metabolism. 

Primary Hemostasis, Cellular Components Platelet Count Direct determination of the number of platelets per unit volume Platelet number Diagnosis of thrombocytopenia Generally none, but insensitive to defective function... 

There are several FKBP genes reported to have a defective function in inherited diseases, such as the Williams Beuren syndrome (Williams syndrome) and Leber s congenital amaurosis for FKBP36 (FKBP6) and FKBP44 (AIPL1) mutations, respectively [97-99],... 

The highest occupied molecular orbital (HOMO) and lowest unoccupied molecular orbital (LUMO) energy levels of fluorenone are shown in Fig. 4.28. Consistent with charge trapping, the fluorenone defects function as both a hole trap and an electron trap the HOMO and LUMO of fluorenone fall within the Jt-it gap of PFO [47]. In addition, the hole (electron) can be injected from the PEDOT PSS (Ca) electrode directly into the HOMO (LUMO) of fluorenone because of the small energy barrier between PEDOT PSS and the HOMO (or between Ca and the LUMO) of fluorenone. 

The defective function in four types of mesenchymal cells explains the growth of pathological lesions in scurvy so satisfactorily that there can be no doubt about the essential soundness of this generalization. The cellular defects explain not only the radiological changes in the epiphyses of long bones, but also the generalized osteoporosis. This develops when new bone formation ceases, while bone dissolution continues unabated. 

Ross and Jungen (1999) have used differences between ab initio ion-core and Rydberg state potential curves to determine quantum defect functions. Thus the independent quantum defect functions associated with the atom-like Hel(°) and the molecular H 1) are, respectively, ai(R) and ai (R). 

The mechanism leading to more hypothyroidism with higher iodine intake has not been fully elucidated. A high iodine load to the thyroid leads to inhibition of many thyroidal processes involved in hormone synthesis and secretion. Normally the thyroid will escape from this inhibition via downregulation of NIS and a subsequent fall in thyroidal iodide uptake (Eng et al., 1999). Apparently, this escape process is not fuUy effective in many people, especially people with a partly defective function of the thyroid because of thyroid autoimmunity or previous thyroid disease. 

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