Cataract prevention

Barbizhayev, M. A. (2005). Analysis of lipid peroxidation and electron microscopic survey of maturation stages during human cataractogenesis Pharmacokinetic assay of Can-C N-acetylcamosine prodrug lubricant eye drops for cataract prevention. Drugs 6, 345-369. 

Unlabeled Uses Cataract prevention, menorrhagia, osteoarthritis, rheumatoid arthritis... 

J2. Jaques, P. F., and Chylack, L. T., Jr., Epidemiologic evidence for a role for the antioxidant vitamins and carotenoids in cataract prevention. Am. J. Clin. Nutr. 53, 353S-355S (1991). 

Robertson JM, Donner AP, Trevithick JR. A possible role for vitamins C and E in cataract prevention. Am J Clin Nutr 1991 53 346S-351S. 

Gerster, H., 1989, Antioxidant vitamins in cataract prevention, Z. Erndhrungswiss, 28 56-75. 

So far, it is not possible to give any recommendations concerning the vitamin C intake required for the prevention of osteoporosis, cataracts, cancer, or cardiovascular disease. 

Martensson, J., Steinherz, R, Jain, A. and Meister, A. (1989). Glutathione ester prevents buthionine sulfoxamine-induced cataracts and lens epithelial damage. Proc. Natl Acad. Sci. USA 86, 8727-8731. 

Inhibitors of AR have been demonstrated to prevent a wide variety of biochemical, functional and structural alterations in animal models of diabetes. Early studies demonstrated arrest of both early cataract development and nerve conduction velocity. At least 30 clinical trials of AR inhibitors have been published involving nearly 1000 patients in total. However, there is little impressive data of their efficacy up to now but, rather than undermine the hypothesis linking excess polyol pathway activity to diabetic complications, it may reflect methodological difficulties and trial design errors. 

Excessive activity of the enzyme aldose reductase sometimes accompanies diabetes. The net result is often accumulation of reduced sugars such as galactose in the lens of the eye and ensuing cataract formation. A1 restatin (43), an aldose reductase inhibitor, is one of the first agents found that holds promise of preventing diabetes-induced cataracts. The compound, actually used as its sodium salt, is prepared in straightforward manner by imide formation between 1,8-naphthalic anhydride (41) and glycine. ... 

Bilberry Vaccinium myrtillus) Uses Prevent/treat visual problems such as cataract, retinopathy, myopia, glaucoma, macular degeuCTation treat vascular problems such as hemorrhoids, varicose veins Actions Contains anthocyanidin that X vascular permeability, inhibit pit aggregation thrombus formation, t antioxidant effects on LDLs liver, t regeneration of rhodopsin... 

Mechanism of Action Aphenylalkanoicacid that produces analgesic and anti-inflammatory effect by inhibiting prostaglandin synthesis. Also relaxes the iris sphincter Therapeutic Effect Reduces the inflammatory response and intensity of pain. Prevents or decreases miosis during cataract surgery. 

Wear UVA-absorbing sunglasses for 24 hr following treatment to prevent cataract... 

MDX-RA , an immunotoxin conjugated to an antibody designed to prevent secondary cataracts, phase III clinical trials, enrollment stopped. Medarex, Annandale, NJ. 

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