Catalysis molecular recognition and

In the above two independent studies, the feasibility of CPMV as a nanobuilding block for chemical conjugation with redox-active compounds was demonstrated. The resulting robust, and monodisperse particles could serve as a multielectron reservoir that might lead to the development of nanoscale electron transfer mediators in redox catalysis, molecular recognition, and amperometric biosensors and to nanoelectronic devices such as molecular batteries or capacitors. 

The transmetalation of organotin derivatives to their indium counterparts (Scheme 1) has recently been used to investigate a new route to Group 13 polyfunctional Lewis acids, which are becoming important in catalysis, molecular recognition, and materials synthesis. ... 

The 4,4 -bipyridine ligand has been utilized in the synthesis of linear coordination polymers as well as grids and networks through reaction with transition metal ions. These inorganic-organic polymers and frameworks are potential candidates for use in catalysis, molecular recognition, and nonlinear optics.257-262... 

Macroheterocyclic systems with 1,1 -binaphthyl fragments in molecular recognition and asymmetric catalysis 98CRV2405. 

Proteins derive their powerful and diverse capacity for molecular recognition and catalysis from their ability to fold into defined secondary and tertiary structures and display specific functional groups at precise locations in space. Functional protein domains are typically 50-200 residues in length and utilize a specific sequence of side chains to encode folded structures that have a compact hydrophobic core and a hydrophilic surface. Mimicry of protein structure and function by non-natural ohgomers such as peptoids wiU not only require the synthesis of >50mers with a variety of side chains, but wiU also require these non-natural sequences to adopt, in water, tertiary structures that are rich in secondary structure. 

In recent years, the development of metalated container molecules has also become an attractive research goal (35-38). This is mainly due to the fact that such compounds allow for an interplay of molecular recognition and transition-metal catalysis (39-41). Consequently, several research groups are involved in the development of new receptor molecules that create confined environments about active metal coordination sites. The aim of this review is to highlight recent advances in this area. 

M. W. Hosseini, A. J. Blacker, and J.-M. Lehn, Multiple molecular recognition and catalysis, nucleotide binding and ATP hydrolysis by a receptor molecule bearing an anion binding site, an intercalator group, and a catalytic site, J. Chem. Soc., Chem. Commun. 596(1988). 

A clear, brief, quantitative discussion of the contribution of hydrogen bonding to molecular recognition and enzyme catalysis. 

Beyond generating novel species for the study of molecular recognition and nucleic acid catalysis, these experiments can provide fundamental insights into the nature of the landscapes that govern molecular evolution. By analyzing the relationships between selected sequences and their attendant functions, we can better understand how difficult it may be to chance upon function, and what the probable course of evolution may be once a nascent function has been discovered. 

M. R. Pincus and H. A. Scheraga, Acc. Chem. Res., 14,299 (1981). Theoretical Calculations on Enzyme-Substrate Complexes The Basis of Molecular Recognition and Catalysis. 

V. Jubian, R.P. Dixon, A.D. Hamilton, Molecular Recognition and Catalysis - Acceleration of Phosphodiester Cleavage by a Simple Hydrogen-Bonding Receptor , J. Am. Chem. Soc., 114, 1120 (1992)... 

MOLECULAR RECOGNITION AND CATALYSIS WITH STOICHIOMETRIC NON-COVALENT INTERACTIONS... 

Protein engineering is of very wide interest, offering the potential to provide new or better enzymes. As we begin to understand the process of molecular recognition and catalysis in flavocytochrome 2 in more detail, we should increase the scope for rational redesign of this enzyme. 

As already noted in Section 1, autocatalysis occurs in the carbazolediimide system. Addition of the product increased the rate of the couphng reaction of the ester (12) with amine (4) in 13% THF-CHCI3. Experiments at 6.2mM showed a 54% increase in initial rate with half an equivalent of added (13). Just as with the naphthoyl-based replicator, the carbazolediimide system was extensively tested using various control molecules to assure that autocatalysis was due to molecular recognition and not to trivial chemical catalysis by some functionahty of the template. The results are summarized in Figure 21 and Table 4. 

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