New chiral benzothiazine ligand for catalysis and molecular recognition

7 New Chiral Benzothiazine Ligand for Catalysis and Molecular Recognition 

A new chiral benzothiazine ligand 205 was synthesized by Harmata and co-workers 06JOC3650 . It could be converted into a chiral molecular receptor 207 in a simple way. This chiral species 207 could be used as a new class of chiral molecular tweezers. The synthesis of 205 commenced with the protection of the commercially available compound 202, which was then coupled with f7tj-sulfoximinc 77b using the one-pot, one-operation procedure 99AG(E)2419 affording enantiomerically pure benzothiazine 204. This was followed by deprotection to produce benzothiazine 205 in good yield. 

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