Carrageenan induced edema

Caryophyllidae are an interesting source of oligosaccharides and peptides with potential anti-inflammatory and/or immunomodulating effect. These polar compounds might for instance explain the fact that the fresh juice expressed from Aerva lanata (L.) Juss. (Amaranthaceae) inhibits carrageenan-induced edema in rodent. Note that the seeds of Gomphrena species inhibit the formation of IL-6 by osteoblastic cells (MC3T3-E10) without cytotoxicity in vitro. Such property could be useful for the treatment of chronic rheumatoid arthritis, infection, and cancer. In the Lauraceae, trans-cinnamal-dehyde from Cinnamomum cassia (Lauraceae, order Laurales) inhibits in vitro the... 

Antiinflammatory effects of astramembrannin I (astragaloside IV), isolated from A. membranaceus, were demonstrated in rats. This compound inhibited the increase of vascular permeability induced by serotonin or histamine. Oral administration of astramembrannin I caused a dose dependent reduction in carrageenan-induced edema of the hind paw of rats [15]. 

Log of percent inhibition of carrageenan-induced edema, log %CPE, in mice Eq. 8... 

A number of alkaloids producing a pronounced enhancement of phagocytosis were isolated by Wagner et al. (20) As a part of our continuing search for new biologically active metabolites from U. tomentosa we preceded to a bioassay-directed fractionation of the extracts from V. tomentosa. The extracts and fractions have been bioassayed by the carrageenan induced edema test on rat paw. This allowed us to identify a quinovic acid derivative with a C-3,27 glycosidation pattern, 21. as one of the active anti-inflammatory principles of U. tomentosa. (11). 

The root bark of V. tomentosa was extracted with solvents of increasing polarity (Petroleum ether, CHQ3, CHCl3-MeOH 9 1, MeOH and H2O). Each extract was tested orally using the carrageenan induced edema in rat paw administrering 2g/Kg of dry bark. 

S fruiescens Inflammation Anti-inflammatory On carrageenan-induced edema in rat.. [123]... 

Carrageenan- and zymosan- induced paw edema were chosen as suitable models for evaluation of the antiinflammatory activities of TE2 and esculin (Table 14). The results showed that both TE2 and esculin significantly reduced formation of the zymosan-induced paw edema in mice. In the case of carrageenan-induced edema, only TE2 at a dose of 15 mg/kg significantly reduced the inflammation, while esculin was ineffective. This indicated that the extract contains active components with different mode of action. 

Onishi, H., Koyama, K., Sakata, O., Machida, Y., 2010. Preparation of chitosan/alginate/ calcium complex microparticles loaded with lactoferrin and their efficacy on carrageenan-induced edema in rats. Drug Dev. Ind. Pharm. 36 (8), 879-884. 

In another study of the effects of A -THC on yeast-induced pyrexis, carrageenan-induced edema and yeast-induced rat paw hyperesthesia, the following results were obtained (l) The oral antipyretic potency of A -THC is approximately 2 times that of phenylbutazone, (2) A -THC was essentially devoid of antinociceptive activity except at elevated doses which produced a marked catatonic-like state, and (3) A -THC at doses up to and including 100 mg/kg was totally ineffective in reducing or preventing the edematous response. 

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