Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Cardiovascular diseases thrombosis

Supplements of 400 Ig/d of folate begun before conception result in a significant reduction in the incidence of neural mbe defects as found in spina bifida. Elevated blood homocysteine is an associated risk factor for atherosclerosis, thrombosis, and hypertension. The condition is due to impaired abihty to form methyl-tetrahydrofolate by methylene-tetrahydrofolate reductase, causing functional folate deficiency and resulting in failure to remethylate homocysteine to methionine. People with the causative abnormal variant of methylene-tetrahydrofolate reductase do not develop hyperhomocysteinemia if they have a relatively high intake of folate, but it is not yet known whether this affects the incidence of cardiovascular disease. [Pg.494]

Accumulation of homocystine in blood is associated with cardiovascular disease deep vein thrombosis, thromboembolism, and stroke dislocation of the lens (ectopic lens) and mental retardation. Homocystinemia caused by an enzyme deficiency is a rare, but severe, condition in which atherosclerosis in childhood is a prominent finding. These children often have myocardial infarctions before 20 years of age. Ail patients excrete high levels of homocystine in the urine. Treatment includes a diet low in methionine. The two major enzyme deficiencies producing homocystinemia are ... [Pg.249]

Cardiovascular disorders Estrogen and estrogen/progestin therapy have been associated with an increased risk of cardiovascular events (eg, Ml and stroke, venous thrombosis, PE [venous thromboembolism]). Manage risk factors for cardiovascular disease appropriately. [Pg.179]

Diagnostic imaging (e.g. of cancer, infectious diseases, cardiovascular disease and deep vein thrombosis)... [Pg.414]

Contraindications for oral contraceptives form episodes of thrombosis or embolism and cardiovascular disease. Estrogen containing pills should not be used immediately postpartum since they can interfere with lactation. [Pg.403]

Estrogens with or without progestins should not be used for the prevention of cardiovascular disease. The Women s Health Initiative (WHI) study reported increased risks of myocardial infarction, stroke, invasive breast cancer, pulmonary emboli, and deep vein thrombosis in postmenopausal women (50 to 19 years of age) during 5 years of treatment with oral conjugated estrogens (0.625 mg) combined with medroxyprogesterone acetate (2.5 mg) relative to placebo.62... [Pg.56]

In view of the perceived benefit of aspirin in the secondary prevention of stroke and myocardial infarction, two large trials involving physicians as subjects were initiated to study the effect of aspirin in the primary prevention of arterial thrombosis. In the American study, 22,000 volunteers (age 40 to 84 years) were randomly assigned to take 325 mg of aspirin every other day or placebo. The trial was halted early, after a mean follow-up of 5 years, when a 45% reduction in the incidence of myocardial infarction and a 72% reduction in the incidence of fatal myocardial infarction were noted with aspirin treatment. However, total mortality was reduced only 4% in the aspirin group, a difference that was not statistically significant, and there was a trend for a greater risk of hemorrhagic stroke with aspirin. Thus, the prophylactic use of aspirin in an apparently healthy population is not recommended at this time, unless there are risk factors for cardiovascular disease. [Pg.413]

C20. Ceriello, A., Bortolotti, N., Motz,E., Lizzio, S., Catone, B., Assaloni, R., Tonutti, L., andTaboga, C., Red wine protects diabetic patients from meal-induced oxidative stress and thrombosis activation A pleasant approach to the prevention of cardiovascular disease in diabetes. Eur. J. Clin. Invest. 31, 322-328 (2001). [Pg.276]

Cardiovascular The most serious side effect of oral contraceptives is cardiovascular disease, including thromboembolism, thrombophlebitis, hypertension, and increased incidences of myocardial infarction and cerebral and coronary thrombosis. These adverse effects are most common among women who smoke and who are over 35 years of age, although they may affect women of any age. [Pg.280]

Cardiovascular disease is characterized by three major events (1) the formation of atherosclerotic plaques on the intima of blood vessels, which reduce the size of the lumen of the vessel (2) thrombosis or clot formation, which is the event leading directly to a coronary attack or stroke in many individuals and (3) cardiac arrhythmias, uncoordinated contractions of the heart muscle resulting in irregular and ineffective... [Pg.739]

Knight, L.C. Antifibrin antibody for detection of deep vein thrombosis. In Monoclonal Antibodies in Cardiovascular Diseases Khaw, B.A., Narula, J., Strauss, H.W., Eds. Lea Febiger Philadelphia, 1994 171-186. [Pg.1166]

Aberrant thrombus formation and deposition on blood vessel walls imderlies the pathogenesis of acute cardiovascular disease states which remain the principal cause of morbidity and mortality in the industrialized world [1,2,3]. Plasma proteins, proteases and specific cellular receptors that participate in hemostasis have emerged as important risk considerations in thrombosis and thromboembolic disorders. The clinical manifestations of the above disease states include acute coronary artery and cerebrovascular syndromes, peripheral arterial occlusion, deep vein thrombosis and pulmonary/renal embolism [3]. The most dilabilitating acute events precipitated by these disorders are myocardial infarction and stroke. In addition, the interplay between hemostatic factors and hypertension (4) or atherosclerosis (5) dramatically enhances the manifestation of these pathologic states. [Pg.271]

Newman AB, Shemanski L, Manolio TA, et al. Ankle-arm index as a predictor of cardiovascular disease and mortality in the Cardiovascular Health Study. The Cardiovascular Health Study Group. Arteriosclerosis, Thrombosis Vascular Biology 1999 19 538-545. [Pg.458]

Approved indications of hormone therapy include treatment of menopausal symptoms and osteoporosis prevention. Therapy directed at menopausal symptoms, such as hot flushes, is often short term. However, therapy directed at prevention of osteoporosis should be long term. For osteoporosis prevention, the advantages of hormone therapy must be weighed against risks, including thrombosis and the increased incidence of cardiovascular disease and breast cancer, and consideration should be given to approved nonestrogen alternatives. [Pg.1495]

Thrombin (factor Ha) is the last enzyme protease involved in the coagulation cascade, and it converts fibrinogen to insoluble fibrin that forms the fibrin gel either in physiological conditions or in a pathological thrombus (28). Thrombin has also hormonelike properties, and it is involved in thrombosis and platelet activation. Therefore, thrombin plays a central role in a number of cardiovascular diseases (29), and it is thought to regulate many processes in inflammation and tissue repair at the vessel wall. [Pg.25]


See other pages where Cardiovascular diseases thrombosis is mentioned: [Pg.170]    [Pg.26]    [Pg.251]    [Pg.336]    [Pg.448]    [Pg.627]    [Pg.368]    [Pg.214]    [Pg.224]    [Pg.264]    [Pg.250]    [Pg.448]    [Pg.452]    [Pg.59]    [Pg.477]    [Pg.550]    [Pg.132]    [Pg.320]    [Pg.170]    [Pg.212]    [Pg.162]    [Pg.513]    [Pg.551]    [Pg.1644]    [Pg.1654]    [Pg.1688]    [Pg.551]    [Pg.135]    [Pg.143]    [Pg.111]    [Pg.86]    [Pg.35]    [Pg.400]    [Pg.1283]   
See also in sourсe #XX -- [ Pg.243 ]




SEARCH



Cardiovascular disease

Thrombosis

© 2024 chempedia.info