Verrucous carcinoma

Mitotic effect. STE, administered to the buccal mucosa of 15 female HMT rats, 6 months of age, weekly for 1 year, produced hyperorthokeratosis, acanthosis, numerous binucleate spinous cells, and subepithelial connective tissue hyalinization. Verrucous carcinoma and squamous cell carcinoma were not seen. Karyotyping revealed that lymphocytes of tobacco-treated, as well as control rats, had normal chromosome number and morphology. However, approx 25% of buccal epithelial cells of the tobacco-treated rats were tetraploid and 5% octa-ploid, compared with only 11% tetraploid and no octaploid in the controls. Results indicated that the mitotic process could be disturbed by tobacco treatment b Molluscicidal activity. Water extract of the dried leaf, at a concentration of 168 ppm, produced equivocal effect on Lymnaea luteola . 

Verrucous Carcinoma and Papillary Squamous Cell Carcinoma... 

Verrucous carcinoma (VC) and papillary squamous cell carcinoma (PSCC) have a similar gross appearance, but VC has a pushing leading edge and no atypia, whereas PSCC shows c)rtologic atypia and more typical invasion. 

Kroch BB, Trask DK, Hoffman HT. National survey of head and neck verrucous carcinoma Patterns of presentation, care and outcome. Cancer. 2001 92 110-120. 

Medina JE, Dichtel W, Luna MA. Verrucous-squamous carcinomas of the oral cavity. A clinicopathologic study of 104 cases. Arch Otolaryngol. 1984 10(7) 437-440. 

Fujita S, Senba M, Kumatori A, et al. Human papillomavirus infection in oral verrucous carcinoma genotyping analysis and inverse correlation with p53 expression. Pathobiology. 2008 75(4) 257-264. 

Many studies have shown the association of human papillomavirus (HPV) types 16 and 18 with penile carcinoma in as many as 50% of cases, as well as with penile carcinoma in situ (CIS) and basaloid and warty verrucous varieties in more than 90% of cases (Guerrero et aL 2000 Daling et al. 2005 Pascual et al. 2007). 

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