Lobular carcinoma ductal

Tumor heterogeneity refers to the existence of distinct subpopulations of tumor cells with specific characteristics within a single neoplasm. Breast cancer is a classic example of a heterogeneous disease. First, the term breast cancer does not itself refer to a single disease. Breast cancers include many different diseases including (but not limited to) adenomas, papillomas, invasive ductal carcinoma, ductal carcinoma in situ (DCIS), and lobular carcinoma in situ (LCIS) (6). 

Zhao H, Langerod A, Ji Y et al. Different gene expression patterns in invasive lobular and ductal carcinomas of the breast. Mol Biol Cell 2004 15 2523-2536. 

Iowa Women s Health Study HRT associated most strongly with an increased risk of invasive breast cancer and modest increases in risk of invasive ductal or lobular carcinoma of the breast (169)... 

In the Iowa Women s Health Study of postmenopausal women for 11 years, during which 1520 specific breast cancers occurred in the at-risk cohort of 37 105 women, it was concluded that exposure to hormone replacement therapy was associated most strongly with an increased risk of invasive breast cancer with a favorable prognosis. There was a more modest increase in the risk of invasive ductal or lobular carcinoma of the breast (169). 

Li Cl, Weiss NS, Stanford JL, Daling JR. Hormone replacement therapy in relation to risk of lobular and ductal breast carcinoma in middle-aged women. Cancer 2000 88(ll) 2570-7. 

Salivary gland carcinoma Breast ductal-lobular carcinoma... 

Cell Adhesion Ductal versus Lobular Carcinoma... 

Based on cell cohesiveness, the two broad categories of breast carcinoma (invasive and in situ) are ductal and lobular types. Ductal carcinoma in situ increases the risk of invasive malignancy at the local site. Lobular carcinoma in situ is considered a marker of generalized increased risk of invasive malignancy, although some recent data suggest precursor properties for lobular carcinoma in situJ Invasive ductal carcinomas are often unifocal lesions compared to invasive lobular carcinomas, which are often multifocal or more extensive than... 

FIGURE 19.20, cont d A dual ECAD-p120 stain demonstrates membranous ECAD and pi 20 (reddish-brown) immunoreactivity in the ductal component with lack of ECAD (absence of brown staining) but strong cytoplasmic pi 20 (red) staining in this example of mixed ductal and lobular carcinoma (F)-... 

Li Cl, Malone KE, Saltzman BS, et al. Risk of invasive breast carcinoma among women diagnosed with ductal carcinoma in situ and lobular carcinoma in situ, 1988-2001. Cancer. 2006 106 2104-2112. 

Maluf H, Koerner F. Lobular carcinoma in situ and infiltrating ductal carcinoma frequent presence of DCIS as a precttrsor lesion. Int J Surg Pathol. 2001 9 127-131. 

Mersin H, Yildirim E, Gulben K, et al. Is invasive lobular carcinoma different from invasive ductal carcinoma Eur J Surg Oncol. 2003 29 390-395. 

Tubiana-Hulin M, Stevens D, Lasry S, et al. Response to neoadjuvant chemotherapy in lobular and ductal breast carcinomas A retrospective study on 860 patients from one institution. Ann 0 co/. 2006 17 1228-1233. 

Lehr HA, Folpe A, Yaziji H, et al. Cytokeratin 8 immunostain-ing pattern and E-cadherin expression distinguish lobular from ductal breast carcinoma. Am J Clin Pathol. 2000 114 190-196. 

Frolik D, Caduff R, Varga Z. Pleomorphic lobular carcinoma of the breast Its cell kinetics, expression of oncogenes and tumour suppressor genes compared with invasive ductal carcinomas and classical infiltrating lobular carcinomas. Histopathology. 2001 39 503-513. 

Sneige N, Wang J, Baker BA, et al. Clinical, histopathologic, and biologic features of pleomorphic lobular (ductal-lobular) carcinoma in situ of the breast A report of 24 cases. Mod Pathol. 2002 15 1044-1050. 

About 30% of unselected breast carcinomas are associated with HER-2 overexpression most of them are invasive ductal carcinoma, infiammatory breast cancer, Paget s disease as well as breast cancer arising in pregnant women, whereas invasive lobular carcinoma, mucinous carcinoma and medullary carcinoma of the breast are rarely accompanied by HER-2 overexpression. HER-2 overexpression is also found in a significant percentage of male breast carcinomas (about 30%). 

Diekmann F, Diekmann S,Beljavskaja M,et al (2004) [Preoperative MRT of the breast in invasive lobular carcinoma in comparison with invasive ductal carcinoma]. Rofo 176 544-954 Diekmann F, Sommer A, Lawaczeck R, et al (2007b) Contrast-to-noise ratios of different elements in digital mammography evaluation of their potential as new contrast agents. Invest Radiol 42 319-325... 

No significant differences were found between pre-and postmenopausal patients, between lobular and ductal carcinomas, and between tumors in the upper versus lower quadrants. No correlation between pathological staging or grading and the number of p02 readings at zero level, the p02 readings from 0 to 2.5 mmHg, the... 

Estrogen + dydrogesterone was associated with a significant increase in the risk of lobular carcinoma (RR = 1.7 95% Cl = 1.1, 2.6). Estrogen + other progestagens was associated with significant increases in the risks of ductal carcinomas (RR = 1.6 95% Cl = 1.3, 1.8), lobular carcinomas... 

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