Lobular carcinoma in situ

This prevention was evident in all risk category groups included in Gail s score and with any previous history of breast lesions (atypical hyperplasia, lobular carcinoma in situ, etc.) (Fig. 10.7). 

Tumor heterogeneity refers to the existence of distinct subpopulations of tumor cells with specific characteristics within a single neoplasm. Breast cancer is a classic example of a heterogeneous disease. First, the term breast cancer does not itself refer to a single disease. Breast cancers include many different diseases including (but not limited to) adenomas, papillomas, invasive ductal carcinoma, ductal carcinoma in situ (DCIS), and lobular carcinoma in situ (LCIS) (6). 

Based on cell cohesiveness, the two broad categories of breast carcinoma (invasive and in situ) are ductal and lobular types. Ductal carcinoma in situ increases the risk of invasive malignancy at the local site. Lobular carcinoma in situ is considered a marker of generalized increased risk of invasive malignancy, although some recent data suggest precursor properties for lobular carcinoma in situJ Invasive ductal carcinomas are often unifocal lesions compared to invasive lobular carcinomas, which are often multifocal or more extensive than... 

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Elsheikh TM, Silverman JF. Follow-up surgical excision is indicated when breast cote needle biopsies show atypical lobulat hyperplasia or lobular carcinoma in situ A correlative study of 33 patients with review of the litetatute. Am J Surg Pathol. 2005 29 534-543. 

Li Cl, Malone KE, Saltzman BS, et al. Risk of invasive breast carcinoma among women diagnosed with ductal carcinoma in situ and lobular carcinoma in situ, 1988-2001. Cancer. 2006 106 2104-2112. 

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Cangiarella J, Guth A, Axelrod D, et al. Is surgical excision necessary for the management of atypical lobular hyperplasia and lobular carcinoma in situ diagnosed on core needle biopsy A report of 38 cases and review of the literature. Arch Pathol Lab Med. 2008 132 979-983. 

Vos GB, Gleton-Jansen AM, Berx G, et al. E-cadherin inactivation in lobular carcinoma in situ of the breast An early event in tumorigenesis. BrJ Cancer. 1997 76 1131-1133. 

Goldstein NS, Kestin LL, Vicini FA. Glinicopathologic implications of E-cadherin reactivity in patients with lobular carcinoma in situ of the breast. Cancer. 2001 92 738-747. 

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Sneige N, Wang J, Baker BA, et al. Clinical, histopathologic, and biologic features of pleomorphic lobular (ductal-lobular) carcinoma in situ of the breast A report of 24 cases. Mod Pathol. 2002 15 1044-1050. 

Lobular carcinoma in situ Tins ccmdifion b ins in file milk-making glands... 

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