Carcinogens rats, dietary levels

In summary, it has been shown that dietary protein levels can influence the metabolism of the mycotoxin AFBi. Altered metabolism is, in part, responsible for the protective role of low protein diets with respect to carcinogenicity and possibly with its increased toxicity in protein deficient rats. Dietary protein levels can also influence the promotional phase of carcinogenesis. Further research is required to determine the mechanisms associated with the influence of dietary protein on both the initiation and promotional phases of carcinogenesis. 

Rat and Mouse A chronic toxicity/carcinogenicity study was performed, with imidacloprid administered to male and female Wistar rats for 12 months and 2 years at dietary levels of 100, 300, 900, and 1800 ppm. These dietary concentrations resulted in average daily dosages of 5.7, 17, 51, and 103 mg kg for males, and 7.6, 25, 73, and... 

Wogan GN, Paglialunga S, Newbeme PM. 1974. Carcinogenic effects of low dietary levels of Aflatoxin B in rats. Food Cosmet. Toxicol. 12 681—85... 

Table II. Carcinogenic Effects of Dietary Levels of Aflatoxin Bi in Rats...

Vanillin has a low potential for acute and chronic toxicity, with a reported oral LD q in rats of 1580—3300 mg/kg. Dietary doses up to 20,000 ppm adrninistered to rats for two years resulted in no adverse toxicologic or carcinogenic effects. Vanillin is classified as a GRAS substance by EEMA. Consequently, at levels normally found in the human diet, vanillin would present no significant health or carcinogenic risk to humans. 

The carcinogenicity of decaBDE was also evaluated in Sprague-Dawley rats (25/sex/dose) that were exposed to dietary doses of 0, 0.01, 0.1, or 1.0 mg/kg/day for approximately 2 years (702 days for males, 735 days for females) (Kociba et al. 1975 Norris et al. 1975b). The commercial mixture was comprised of 77.4% decaBDE, 21.8% nonaBDE, and 0.8% octaBDE and therefore differs from typical decaBDE formulations containing 97% decaBDE. Comprehensive histological examinations showed no exposure-related neoplastic effects. Tlie ability of this study to detect carcinogenic changes is limited by the very low dose levels in comparison to those tested in the NTP (1986) bioassay. 

Acephate is classified as a possible human carcinogen. Since acephate is used both on food crops and other common residential areas, risks of human exposures through multiple routes are high. Based on cholinesterase inhibition studies in rats, the noobserved-adverse-effect level for chronic dietary exposure is 0.12 mg kg day Agricultural workers who are involved in mixing, formulation, and application may be at higher risk of exposure. 

A 2 year carcinogenicity study was conducted in rats with dietary administration resulting in average daily doses of cerivastatin of 0.007, 0.034, or 0.158 mg kg The high dosage level corresponded to plasma free drug levels (AUC) of approximately two times those in humans following a 0.8 mg oral... 

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