Environmental carcinogenity

Hrudey, S. and Krewski, D. (1995) Is there a safe level of exposure to a carcinogen Environmental Science and Technology. 29, 370A. 

Ashby, J. (1985) Fundamental structural alerts to potential carcinogenicity or non-carcinogenicity. Environmental Mutagenesis, 7, 919—921. 

Process development chemists make every effort to avoid using Class 1 solvents (Table 3) for the crystallization of APIs. The solvents in Table 3 pose carcinogenic, environmental, or other toxicity risks. 

Symposium, The Role of Metabolic Activation in Producing Mutagenic and Carcinogenic Environmental Chemicals, February 9-11 Research Triangle Park, N.C. 

L, Popov, T.A., Garte, S., Taioli, E., Gabelova, A., Cebulska-Wasilewska, A. (2003). Molecular epidemiology studies of carcinogenic environmental pollutants. Effects of polycyclic aromatic hydrocarbons (PAHs) in environmental pollution on exogenous and oxidative DNA damage. Mutat. Res. 544 397 02. 

Electrospray mass spectrometry has been used to identify and aid characterisation of covalently linked aromatic compounds to guanosine units. Such adducts are biomarkers used to quantify exposure to mutagenic and carcinogenic environmental substances, and the method described may be used to characterise intact DNA-adducts. 

Other series which have been produced by lARC are Information Bulletin on the Survey of Chemicals Being Tested for Carcinogenicity, Environmental Carcinogens. Methods of Analysis and Exposure Measurements, Scientific Publications and Technical Reports. 

This study represents an on-going research programme whose aim is to detect exposures to mutagenic and carcinogenic environmental chemicals, and which will provide an estimate, in the future, of the magnitude of exposures that may increase the risk of cancer incidence ot birth defects in the population. 

Safety/Toxicity Acute and subacute toxicity,"" carcinogenicity,"" environmental contaminants," estrogenicity," genotoxicity,"" hypersensitivity," mutagenicity,"" photoinduced toxicity,"" synergistic toxicity" ... 

Safety/Toxicity Carcinogenicity, environmental analysis, dye-induced cholestasis, mutagenicity, Nephrotoxocity °... 

Gold, L. S., T. H. Slone, N. B. Manley, and L. Bernstein. Target Organs in Chronic Bioassays of 533 Chemical Carcinogens. Environmental Health Perspectives 93 (1991) 233-46. 

Zhu, H., Rusyn, I., Richard, A. M., 8c Tropsha, A. (2008). Use of cell viability assay data improves the prediction accuracy of conventional quantitative structure-activity relationship models of animal carcinogenicity. Environmental Health Perspect, 116, 506. 

Industrial Applications Electrochromic display devices inks paints photographic materials detergents textiles wood entertainment products Safety/Toxicity Acute toxicity carcinogenicity environmental toxicity genotoxicity mutagenicity ... 

Toxicology Causes eye irritation si. to mod. skin irritation ing. may cause nausea and vomiting carcinogenic Environmental Mod. toxic to aquatic organisms... 

Toxicology LD50 (oral, rat) >50 - 500 mg/kg ACGIH TLV1000 ppm may be corrosive to eyes may cause irritation to the respiratory system excessive inh. causes headache, dizziness, nausea and loss of motor skills not listed as carcinogenic Environmental 5% RVOC biodeg. 

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