2-Carboxy-3-methyl-6-nitro

Alkylation of ll-mercaptopyrido[l,2-h]cinnolin-6-ium hydroxide inner salts (e.g., 41) with ethyl bromoacetate gave ll-(ethoxycarbonylmethyl(thio derivatives 64 (R = H), which could be hydrolyzed to the ll-(carboxy-methyl)thio derivative or back to the starting compound 41 (74JHC125). Hydrolysis of the ll-bis(methoxycarbonyl)methylene 66 (R = H), and 2-cyano derivatives of 17 (R = H) in boiling HCl afforded 11-methyl and 2-carboxylic acid derivatives, respectively (74JHC125). The 2-nitro derivative of 17 (R = H) was reduced to the 2-amino derivative over Pd/C with NaBH4 in aqueous methanol, and the 2-amino group was acylated with acetic anhydride at 100°C. [Pg.106]

The reaction of p-nitro-N,N-dimethylaniline with ozone was studied. Only side-chain oxidation products, p-rafro-N-methylaniline, p-nitro-N-methylformanilide, and a dimeric peroxide, di- [(N-methyl-N-p-nitrophenyl)aminomethyl peroxide, were formed. No N-oxide could be obtained. For comparison 2-carboxy-4-nitro-N,N-dimethylaniline, p-chloro-N,N-dimethylaniline, and N,N-dimethylaniline were ozonized. A mechanism is proposed. [Pg.101]

Malonsaure Nitro- -diethylester VIII, 613 (Nitrier.) X/l, 15, 101 (Nitrier.), 121 (Oxim-Oxid.) Propansaure 3-(Bis-[carboxy-methyl]-amino)- Xl/2, 406... [Pg.397]

Amino-3-phenyl- -(carboxy-methyl-amid) XV/2, 227 2,2-Dimethyl- -(4-nitro-anilid) E5, 948 (OH - NH-Ar)... [Pg.895]

Malonsaure (2-Nitro-l-phenyl-ethyl)- -dimethylester X/l, 372 Propansaure 2-(Benzy oxycarbo-nylamino)- -(carboxy-methyl-ester) XV/2, 374 Z-Asp-OMe XV/1, 322... [Pg.1148]

Durch Einwirkung von waBriger Kaliumhydroxid-Losung auf 4-[Ethoxycarbonyl-(2-phenyl-hydrazono)-methyl]-l, 3-dinitro-benzol (R = OC2H5) tritt Cyclisierung unter Abspaltung der Nitro-Gruppe zu 3-Carboxy-6-nitro-1 -phenyl-1 H-indazol (R = OH)176, l7X- 57°-571 ein. [Pg.786]

Carboxy-5-hydroxy- 834 3-(Carboxy-methyl)- 770, 775, 778 3-Carboxy-5-mcthyl- 817 3-(Carboxy-methyl)-5-chlor- 775 3-Carboxy-6-nitro-l-phenyl- 786, 817 3-(2-Carboxy-phenyl)- 799 3-Chlor- 111, 778, 813, 838, 839, 839 6-Chlor- 815... [Pg.1196]

Alkyl-aryl sulfonates CMC (Carboxy-methyl-cellulose) Nitro-penta-erythritol... [Pg.1386]

Thiazolo[3,2-a]pyridinium salts, 3-carboxy-2,3-dihydro-8-hydroxy-8-methyl-desulfbrization, 6, 687-688 Thiazolo[3,2-a]pyridinium salts, 6(8)-nitro-2,3-dihydro-... [Pg.877]

Anti-mycobacterium avium activity in vitro of 3-carboxy-7-methyl-6-nitro-l-ethyl-l,8-naphthyridin-4(lH)-one (6-nitro derivative of nalidixic acid) was demonstrated (93MI1). [Pg.339]

Dimethylamino-methyl)-2-hydroxymethyl-aus 2 -Carboxy-2-(dimethylaminocarbonyl)-biphenyl und Lithiumalanat 165 2,2 -Dinitro- 474, 476, 695 6,6 -Dinitro-2,2 -bis-[chlorcarbonyl]- 188 2,2 -Dinitro-4,4 -bis-[diathylamino]- 695 4,4 -Dinitro-2,2 -bis-rhydroxymethyl]- 213 6,6 -Dinitro-2,2 -bis-[hydroxymethyl]- 188 2,2 -Dinitro-4,4 -diamino- 695 6,6 -Dinitro-2,2 -diformyl- 694 4,4 -Dinitro-2,2 -dimethoxycarbonyl- 213 2,2 -Dinitro-4,4 -dimethyl- 695 6,6 -Dinitro-2 -formyl-2-carboxy- 694 2,2 -Dinitroso- 476 -4-hydroxamsaure-chlorid 537 4-(a-Hydroxy-benzyl)- 542 Methoxy- 678 2-Methyl- 556 Nitro- 672, 678 4-Nitro- 687... [Pg.976]

Nitro-2-athoxycarbonyl- 694 2 -Nitro-2-carboxy- 694 2-Nitro-2 -formyl- 693 Octachlor-4,4 -bis-[trichlor-vinyl]- 62 7 Octachlor-4,4 -diathinyl- 627 Octachlor-4 -(trichlor-vinyl)-4-athinyl- 627 2,2, 6,6 -Tetrakis-[hydroxyamino]- 695 2,2, 6,6 -Tetranitro- 695 2,2, 4,4 -Tetranitro-6.6 -dicarboxy- 689 4,4, 6,6 -Tetranitro-2,2 -dicarboxy- 660 2-(Trichlorsilyl-methyl)- 555... [Pg.976]

Directed osmylation.J One step in a synthesis of the carbonucleoside aris-teromycin (3) required dihydroxylation of the intermediate 1, in which a (nitro-phenylsulfonyl)methyl group is used as a carboxy equivalent. The desired diol (2)... [Pg.236]

G. Pilcher, W. E. Acree Jr., J. R. Powell. Enthalpies of Combustion of the Pyridine N-oxide Derivatives 4-Methyl-, 3-Cyano-, 4-Cyano-, 3-Hydroxy-, 2-Carboxy-, 4-Carboxy-, and 3-Methyl-4-Nitro, and of the Pyridine Derivatives 2-Carboxy- and 4-Carboxy-. The Dissociation Enthalpies of the N-O Bonds. J. Chem. Thermodynamics 1998, 30, 869-878. (b) M. D. M. C. Ribeiro da Silva, personal communication. [Pg.249]

HOOC-(CIl2)3-Br KOH 1-(3-Carboxy-propyI)-2-methyl-4-nitro-... 60 144 855... [Pg.116]

Neben Oxiranen oder 2-Oxo-l,3-dioxolan werden zur N-Alkylierung von Imidazolen manch-mal auch andere Heterocyclen verwendet, die in der Lage sind, unter Ringoffnung Nukleophile zu addieren. So kann 2-Methyl-4(5)-nitro-imidazol mit l,2-Oxathiolan-2,2,-dioxid (Propansul-ton) zu 2-Methyl-5-nitro-l-(3-sulfo-propyl)-imidazol (48%) und mit 2-Oxo-oxetan zu l-(2-Carboxy-ethyl)-2-methyl-4-nitro-imidazol umgesetzt werden875. [Pg.119]

Fur Brom-, Nitro- bzw. Carboxy-pentamethyl-benzol bendtigt man nur einen 4-5fachen UberschuB an Nitroniumtetrafluoroborat. Ein elektronenziehender Substituent in o-Stellung beschleunigt offensichtlich die Methyl-Substitution. [Pg.342]

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