Hydroxide Inner Salt

CEA-3175 (1,2,3, 4-Oxatriazolium, -3-(3-chloro-2-methylphenyl)-5-[[(4-methylphenyl) sulfonyljamino]-, Hydroxide Inner Salt) [Pg.246]

GEA-3175 is more stable than GEA-3162 in vitro but still retains its biological activity [95]. The release of NO and NO2 by GEA 3175 was increased 140-fold in the presence of human plasma, as analyzed by ozone chemiluminescence [94]. GEA 3175 inhibited agonist-induced platelet aggregation and induced a more than 4-fold increase in platelet cGMP without affecting cAMP levels [94]. Thrombin-stimulated rises in the cytosolic free Ca2+ concentration and secretion were dose-dependently inhibited by GEA 3175. GEA 3175 showed a reduced capacity to inhibit platelet aggregation of uremic platelets compared to controls [96]. [Pg.246]

The preparation of these [4-hydroxy-THISs, (1), X = O] by cydization of a-carboxy-N-arylthiobenzimides (5) by treatment with acetic anhydride and triethylamine has been investigated in detail, and the structure has been revised for the compound previously described as 2.3-diphenyl-4-hydroxythiazolium hydroxide inner salt (1, X = 0, R = R = Ph, R = H) (Scheme 5) (3, 10). 4-Hydroxy-THlSs also arise by condensation of gem-dicyanoepoxides with thioamides (Scheme 6) (8). [Pg.4]

Irradiation of a 2-methvlthio-4-hydroxythiazolium hydroxide inner salt (12) leads to exchange of the carbon atoms located in the 2 and 4 positions, probably via a thiirenium ion (Scheme 13) (5). [Pg.7]

Mercapto- or 4-alkylidenethia2oIium hydroxide inner salts (1) (X = S or CRR ) have not been described. [Pg.8]

Hydroxvthiazolium hydroxide inner salts (2) (X = 0) have been synthesized by an improved acetic-anhydride-triethylamine-caialyzed cyclization of N-substituied N-thiobenzovlalanines (Scheme 15) (23). [Pg.8]

Hydroxy-THISs add regioselectively to the C=N bonds of isocyanates or isothiocyanates. The initially formed cycloadducts eliminate carbonyl sulfide with formation of 4-hydroxy- or 4-mercaptoimidazolium hydroxide inner salts (21) (Scheme 21). 4-Hydroxyimidazolium hydroxide... [Pg.10]

Mercaptothiazolium hydroxide inner salts (2) (X = S) are prepared from 5-hydroxy-oxazolium inner salts and CS (2, 25). The oxazolium inner salts may advantageously be replaced with their precursors, which are N-arylacylalanins (Scheme 23). [Pg.12]

The 5-methylthiothiazolium salts react with methylamine to give 4-mercaptoimidazolium hydroxide inner salts (25) and with aniline to give 26 (Scheme 24) (32). [Pg.12]

Aminothiazolium hydroxide inner salts (2) (X = NR) are only known as N-phenyl (29) or acyl derivatives. (6. 34) or as hydrochlorides (35). [Pg.13]

Besides being useful precursors to pyrroles pyridine-2-ones -4-ones, -4-thiones. and -4-imines 4-alkylidene-dihydropyridines thiophenes 1,2,4-triazoles thiapyrane-2-thiones, isoquinoline-3-ones isoben-zothiophenes and 4-mercaptoimidazolium hydroxide inner salts, mesoionic thiazoles are potentially useful in the construction of molecules with herbicidic (39). central nerve stimulating, and antiinflammatory properties (40,41). Application in dye synthesis has likewise been reported (42). [Pg.15]

Nitron [l,4-diphenyl-3-phenylamino-(lff)-l,2,4-triazolium (hydroxide) inner salt] [2218-94-2] M 312.4, m 189 (dec). Crystd from EtOH, chloroform or EtOH/ C6H6. [Pg.312]

Chemical Name 3-Carboxy-2-hydroxy-N,N,N-trimethyl-1-propanaminium hydroxide, inner salt... [Pg.250]

Chemical Name (6R-trans)-1-[ [2-Carboxy-8-oxo-7-[(2-thienylacetyl)amino] -5-thia-1-azabi-cyclo[4.2.0]oct-2-en-3-yl] methyl] pyridinium hydroxide inner salt... [Pg.283]

Chemical Name Cytidine 5 -(trihydrogen diphosphate)mono[2-(trimethylammonio)ethyll-ester hydroxide inner salt... [Pg.347]

Chemical Name Endo( )-3-(3-hydroxy-1-oxo-2-phenYlpropOXY)-8-methyl-8-(3-sulfopropYl)-8-azoniabicyclo[3.2.11 octane hydroxide, inner salt... [Pg.1434]

A. Carbobenzoxy-L-asparaginyl-L-lewine Methyl Ester. A mixture of 2.024 g. (0.0080 mole) of A -ethyl 5 phenylisoxazolium-3 -sulfonate [Isoxazolium, 2-ethyl-5-(3-sulfophenyl)-, hydroxide, inner salt] (Note 1) and 20 ml. of nitromethane (Note 2) is prepared in a 50-ml., glass-stoppered Erlenmeyer flask at room temperature and stirred vigorously... [Pg.88]

Ethananunium, N,N -diethyl-A - [ [(methoxy-carbonyl)amino] sulfonyl]. hydroxide, inner salt [29684-56-8], 41 1,2-Ethanediol [107 21-1],44 Ethanethioic acid, tnfluoro-,S-ethyl... [Pg.134]

Isoxazohum, 2-ethyl-5-(3-suIfophenyl)-, hydroxide, inner salt (4156 16-5], 88... [Pg.135]

Allylic oxidation, 25 Aluminum chloride, 28 Amine, dnsopropyl- [2-Propanamine, Af-(l-methylethyl)-], 36 Ammonium, (methoxycarbonylsulfamoyl)-tnethyl-, hydroxide [Ethanaminium, W.W-diethyl-A-t [ (methoxycarbonyl)-amino] sulfonyl] -, hydroxide, inner salt], 41... [Pg.138]

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