2-Carboxy-6-nitro

AD70 C5H3NO4S 2-carboxy-5-nItro-th lophene T5SJ BVCl ENW EtOH 10 PY BR NaC1 0.1 - 1.8 3.8 5.0 6.1 25 DME/SCE 0-0... 

Benzothiophen 2-Carboxy-5-nitro- -Natrium-Salz E6b/1, 226 (2-Cl-Ar-CHO + HS-CH2-COOH)... 

Other electron-withdrawing substituents which have been used to stabilize cyclopropyl anions are the acyl, ° carboxy, ° nitro, and isocyanide groups. With one exception, the first three were unsuccessful, partly because other reactions took place. Thus, cyclopropanecarboxylic acid undergoes dimerization to l-(cyclopropylcarbonyl)cyclo-propanecarboxylic acid, and this reaction predominates above room temperature. When ni-trocyelopropane was treated with base spontaneous dimerization oceurred, yielding mixtures of 1-nitro-l-nitrosobicyclopropyland l,l -dinitrobicyclopropyl. The yields of the two products were dependent on the workup procedure employed. 

Thiazolo[3,2-a]pyridinium salts, 3-carboxy-2,3-dihydro-8-hydroxy-8-methyl-desulfbrization, 6, 687-688 Thiazolo[3,2-a]pyridinium salts, 6(8)-nitro-2,3-dihydro-... 

Table 2.3 shows very obvious parallels with the TMS scale of C shifts. Thus, the shifts (Table 2.3) decrease in size in the sequence nitroso, nitro, imino, amino, following the corresponding behaviour of the shifts of carbonyl, carboxy, alkenyl and alkyl carbon atoms (Table 2.2). 

Anti-mycobacterium avium activity in vitro of 3-carboxy-7-methyl-6-nitro-l-ethyl-l,8-naphthyridin-4(lH)-one (6-nitro derivative of nalidixic acid) was demonstrated (93MI1). 

Natriumboranat/Aluminiumchlorid wird hauptsachlich zur selektiven Reduktion von Carbonsaureestern gebraucht, die neben der Alkoxycarbonyl-Gruppe noch eine Carboxy-Gruppe (in Form des Natrium-Salzes), eine unsubstituierte Amino-carbonyl-Gruppe, eine Nitro- oder Halogcn-Gruppe enthalten. 

Carboxy-, Ester-, Aminocarbonyl-, Cyan- und Nitro-Gruppen werden nicht angegriffen. Die Reduktion sollte unter Stickstoff mit Natriumboranat-Tabletten durchgefiihrt werden, da sich pulverformiges Natriumboranat mit Trifluoressigsaure entziinden kann. 

Azide werden bei Anwesenheit von C-C-Mehrfachbindungen, Carboxy-, Amid-, Ester-, Nitro-, Flalogenaryl-, Oxo- und Cyan-Gruppen bzw. Phosphoramidaten selektiv durch 1,3-Propandithiol zu Aminen reduziert3 ... 

Analog reagieren 3-Nitro-2-aminocarbonyl- und 8-Nitro-l-aminocarbonyl (bzw. carboxy)-naphthalin5 zum 1 -Hydroxy-(naphtho-[2,3-c -1,2-oxazol) bzw. 8-Amino-naphthalin-1 -carbonsaure-lactam ... 

Chlor- -phenylester 192 Diacetamino- -athylester 240 Dichlor- 618 Dichlor- -chlorid 186 Difluor-nitro- -benzylester 211 Difluor-nitro- -isopropylcster 194 (4,5-Dimethoxy-2-carboxy-phenyl)- -methylester 200... 

Dimethylamino-methyl)-2-hydroxymethyl-aus 2 -Carboxy-2-(dimethylaminocarbonyl)-biphenyl und Lithiumalanat 165 2,2 -Dinitro- 474, 476, 695 6,6 -Dinitro-2,2 -bis-[chlorcarbonyl]- 188 2,2 -Dinitro-4,4 -bis-[diathylamino]- 695 4,4 -Dinitro-2,2 -bis-rhydroxymethyl]- 213 6,6 -Dinitro-2,2 -bis-[hydroxymethyl]- 188 2,2 -Dinitro-4,4 -diamino- 695 6,6 -Dinitro-2,2 -diformyl- 694 4,4 -Dinitro-2,2 -dimethoxycarbonyl- 213 2,2 -Dinitro-4,4 -dimethyl- 695 6,6 -Dinitro-2 -formyl-2-carboxy- 694 2,2 -Dinitroso- 476 -4-hydroxamsaure-chlorid 537 4-(a-Hydroxy-benzyl)- 542 Methoxy- 678 2-Methyl- 556 Nitro- 672, 678 4-Nitro- 687... 

Nitro-2-athoxycarbonyl- 694 2 -Nitro-2-carboxy- 694 2-Nitro-2 -formyl- 693 Octachlor-4,4 -bis-[trichlor-vinyl]- 62 7 Octachlor-4,4 -diathinyl- 627 Octachlor-4 -(trichlor-vinyl)-4-athinyl- 627 2,2, 6,6 -Tetrakis-[hydroxyamino]- 695 2,2, 6,6 -Tetranitro- 695 2,2, 4,4 -Tetranitro-6.6 -dicarboxy- 689 4,4, 6,6 -Tetranitro-2,2 -dicarboxy- 660 2-(Trichlorsilyl-methyl)- 555... 

Cell-free supernatants may mediate reductions. The reduction of aromatic nitro compounds by SH was mediated by the hltrate from a strain of Streptomyces sp. that is known to synthesize 2-amino-3-carboxy-5-hydroxybenzo-l,4-quinone (cinnaquinone)... 

Such nucleophilic displacements are likely to be addition-elimination reactions, whether or not radical anions are also interposed as intermediates. The addition of methoxide ion to 2-nitrofuran in methanol or dimethyl sulfoxide affords a deep red salt of the anion 69 PMR shows the 5-proton has the greatest upfield shift, the 3- and 4-protons remaining vinylic in type.18 7 The similar additions in the thiophene series are less complete, presumably because oxygen is relatively electronegative and the furan aromaticity relatively low. Additional electronegative substituents increase the rate of addition and a second nitro group makes it necessary to use stopped flow techniques of rate measurement.141 In contrast, one acyl group (benzoyl or carboxy) does not stabilize an addition product and seldom promotes nucleophilic substitution by weaker nucleophiles such as ammonia. Whereas... 

A recent report shows that 1,2,3,4-benzotetrazine 1,3-dioxide nitroderivatives 73 (R=N O2) are thiol dependent N O-donors and potent activators of the sGC [73]. Activation of the sGC was inhibited in the presence either of ODQ or of the N O scavenger 2-(4-carboxyphenyl)-4,4,5,5-tetramethy]imidazoline-l-oxyl-3-oxide (carboxy-PTIO). All products inhibited A DP-induced aggregation of human platelets, with the potency sequence 7-nitro >5,7-dinitro >5-nitro. 

Directed osmylation.J One step in a synthesis of the carbonucleoside aris-teromycin (3) required dihydroxylation of the intermediate 1, in which a (nitro-phenylsulfonyl)methyl group is used as a carboxy equivalent. The desired diol (2)... 

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