Carbon catabolite

PG production was constitutive and not subject to carbon catabolite repression. Highest yields were on glucose and fructose (upto 10% w/v) (Table 1). Inclusion of pectic compounds had no effect on growth or PG production (data not shown). 

Duetz WA, S Marques, C de Jong, JL Ramos, J G van Andel (1994) Inducibility of the TOL catabolic pathway in Pseudomonas putida (pWWO) growing on succinate in continuous culture evidence of carbon catabolite repression control. J Bacteriol 176 2354-2361. 

Demain AL, Kennel YM, Aharonowitz Y (1979) Carbon catabolite regulation of secondary metabolites, pp 163 -185. In Bull AT, Ellwood DC, Ratledge C (eds) Microbial technology Current state, future prospects, vol 29. Cambridge University Press, Cambridge. 

Several research groups have looked for improved mutants of xylose-fermenting yeasts. One approach has been to use 2-deoxyglucose (2-DOG) to obtain carbon catabolite derepressed strains [259,260]. Strains resistant to 2-DOG are better able to ferment other sugars. Because 2-DOG cannot be metabolized beyond phosphorylation, wild-type cells take it up and phosphorylate it to 2-DOG-6-phosphate, which then represses pathways that metaboHze other sugars such as maltose, sucrose or galactose. 

MLS1 Malate synthase, enzyme of the glyoxylate cycle, involved in utilization of non-fermentable carbon sources expression is subject to carbon catabolite repression localizes in peroxisomes during growth in oleic acid medium... 

As in the commercial PN strains, glucose and sucrose were found to repress PN production in A. nidulans. Compared to lactose-grown cultures, ipnA lacZ expression was reduced with these two carbon sources. " The glucose-dependent repression of many genes in primary metabolism is mediated by the well-characterized carbon catabolite repression (ere) system. While CreA mediates... 

ESPESO, E.A., PENALVA, M.A., Carbon catabolite repression can account for the temporal pattern of expression of a penicillin biosynthetic gene in Aspergillus nidulans. Mol. MicriobioL, 1992, 6,1457-1465. 

Stulke, J. and Hillen, W. (1999) Carbon catabolite repression in bacteria. Curr. Opin. Microbiol, 2, 195-201. 

Arndt, A. and Eikmanns, B.J. (2007) The alcohol dehydrogenase gene adhA in Corynebacterium glutamicum is subject to carbon catabolite repression. /. Bacteriol, 189 (20), 7408-7416. 

Fujita, Y. (2009) Carbon catabolite control of the metabolic network in Bacillus suhtilis. Bioscl Biotechnol, Biochem., 73 (2), 245-259. 

Rojo, F. (2010) Carbon catabolite repression in Pseudomonas optimizing metabolic versatility and interactions with the environment. FEMS Microbiol. Rev., 34 (5), 658 -684. 

H., Burchhardt, G., and Herrmann, H. (1996) Carbon catabolite repression of phenol degradation in Pseudomonas putida is mediated by the inhibition of the activator protein PhlR. /. Bacteriol, 178 (7), 2030-2036. 

Gorke, B. and Stulke, J. (2008) Carbon catabolite repression in bacteria many ways to make the most out... 

Rafudeen, M.S. (2002) Investigation of carbon catabolite repression in Clostridium beijerinckii NCIMB 8052. PhD thesis. University of Cape Town. 

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