Catabolic pathway

Jaworska, J.S., Dimitrov, S., Nikolova, N. and Mekenyan, O. (2002) Probabilistic assessment of biodegradability based on metabolic pathways CATABOL System. SAR OSAR Environ. Res., 13 (2),... 

FIGURE 3 Energy relationships between catabolic and anabolic pathways Catabolic pathways deliver chemical energy in the form of ATP, NADH, NADPH, and FADH2. These energy carriers are used in anabolic pathways to convert small precursor moleculesinto cell macromolecules. 

Simplified schema of the substrate partition between metabolic pathways catabolism (used for ATP and ADP synthesis) and anabolism (for biomass synthesis). The quantities SPi indicate the fraction of S destined to formation of the product "i". 

HMG-CoA lyase is normally present in the mitochondrial matrix.To understand the complexity of the metabolic problems of a patient with HMG-CoA lyase deficiency, it is necessary to consider the role of this enzyme in two very distinct metabolic pathways catabolism of leucine and ketogenesis. 

The PPP handles pentoses and is important for nucleotide (ribose-5-phosphate) and fatty acid biosynthesis (NADPH2). The Entner-Doudoroff pathway catabolizes glucose into pyruvate and glyceraldehyde-3-phosphate. It is important primarily in Gram negative prokaryotes. ... 

While microsomal co-hydroxylation is not believed to represent a major pathway for hepatic fatty acid catabolism under normal physiological conditions, this highly inducible pathway may become important under certain conditions such as fasting or exposure to peroxisome proliferators. In addition to FA catabolism, the cytochrome P450 4As (CYP4As) involved in this pathway catabolize leukotrienes and prostanoids and also generate bioactive molecules from arachidonic acid co-hydroxylation. 

In general, biosynthetic pathways (including fuel storage) are referred to as anabolic pathways, that is, pathways that synthesize larger molecules from smaller components. The synthesis of proteins from amino acids is an example of an anabolic pathway. Catabolic pathways are those pathways that break down larger mol-ecnles into smaller components. Fuel oxidative pathways are examples of catabolic pathways. 

There are two types of metabolic pathways catabolic, involving the breakdown of biochemicals into simpler compounds, and anabolic, involving the synthesis of biochemicals from simpler molecules. Each living cell has thousands of distinct metabolic reactions. Each reaction is catalyzed by an enzyme and is linked to other reactions through a pathway. How can you keep them all straight It is nearly impossible to memorize them. The purpose of this chapter is to provide an organizational framework to metabolism that allows you to view it as something other than a collection of disjointed pathways. 

Diamine oxidase (DAO) is a highly active degradative enzyme of the polyamine metabolic pathways, catabolizes a variety of substrates including histamine and diamines, and is localized to the mature villus epithelial cells of rodent intestinal mucosa (Wolvekamp and de Bruin 1994 John-Baptiste et al. 2012). Although blood DAO activity level correlates with both DAO expression in the villi of the small intestinal mucosa and the severity of small intestinal mucosal lesions induced by anticancer drugs, DAO measurement is confounded by the fact that plasma levels rise markedly upon heparin stimulation prior to blood draws, with peak elevations between 30 and 60 min (Luk et al. 1980, 1981 Tsunooka et al. 2004). 

Catabolic and Anabolic Pathways Catabolic pathways release free energy in the form of ATP and NADH. Anabolic pathways consume energy released by catabolic pathways. 

Furthermore, for each reaction the reaction center was specified, information was given on whether the reaction is reversible or irreversible, and catabolic or anabolic. Finally, it was specified whether a reaction is part of a general pathway or occurs only in unicellular organisms, in higher plants, or in animals (Figure 10.3-21). 

Tryptophan is a precursor for a series of metabolic reactions. Two tryptophan catabolizing pathways are well characterized (i) tryptophan converts to serotonin (ii) tryptophan is also converted to kynurenine. 

Metabolism Consists of Catabolism (Degradative Pathways) and Anabolism (Biosynthetic Pathways)... 

Interestingly, anabolism and catabolism occur simultaneously in the cell. The conflicting demands of concomitant catabolism and anabolism are managed by cells in two ways. First, the cell maintains tight and separate regulation of both catabolism and anabolism, so that metabolic needs are served in an immediate and orderly fashion. Second, competing metabolic pathways are often... 

Certain of the central pathways of intermediary metabolism, such as the citric acid cycle, and many metabolites of other pathways have dual purposes—they serve in both catabolism and anabolism. This dual nature is reflected in the designation of such pathways as amphibolic rather than solely catabolic or anabolic. In any event, in contrast to catabolism—which converges to the common intermediate, acetyl-CoA—the pathways of anabolism diverge from a small group of simple metabolic intermediates to yield a spectacular variety of cellular constituents. 

Corresponding Pathways of Catabolism and Anabolism Differ in Important Ways... 

FIGURE 18.7 Parallel pathways of catabolism and anabolism must differ in at least one metabolic step in order that they can be regulated independently. Shown here are two possible arrangements of opposing catabolic and anabolic sequences between A and P. 

Whereas catabolism is fundamentally an oxidative process, anabolism is, by its contrasting nature, reductive. The biosynthesis of the complex constituents of the cell begins at the level of intermediates derived from the degradative pathways of catabolism or, less commonly, biosynthesis begins with oxidized substances available in the inanimate environment, such as carbon dioxide. When the hydrocarbon chains of fatty acids are assembled from acetyl-CoA units, activated hydrogens are needed to reduce the carbonyl (C=0) carbon of acetyl-CoA into a —CHg— at every other position along the chain. When glucose is... 

Nicotinamide is an essential part of two important coenzymes nicotinamide adenine dinucleotide (NAD ) and nicotinamide adenine dinucleotide phosphate (NADP ) (Figure 18.19). The reduced forms of these coenzymes are NADH and NADPH. The nieotinamide eoenzymes (also known as pyridine nucleotides) are electron carriers. They play vital roles in a variety of enzyme-catalyzed oxidation-reduction reactions. (NAD is an electron acceptor in oxidative (catabolic) pathways and NADPH is an electron donor in reductive (biosynthetic) pathways.) These reactions involve direct transfer of hydride anion either to NAD(P) or from NAD(P)H. The enzymes that facilitate such... 

What are the features that generally distinguish pathways of catabolism from pathways of anabolism ... 

Why is the pathway for the biosynthesis of a biomolecnle at least partially different from the pathway for its catabolism Why is the pathway for the biosynthesis of a biomolecnle inherently more complex than the pathway for its degradation ... 

Vnother pathway of glucose catabolism, the pentose phosphate pathway, is the primary source of N/ E)PH, the reduced coenzyme essential to most reductive biosynthetic processes. For example, N/VDPH is crucial to the biosynthesis of... 

Fatty acids with odd numbers of carbon atoms are rare in mammals, but fairly common in plants and marine organisms. Humans and animals whose diets include these food sources metabolize odd-carbon fatty acids via the /3-oxida-tion pathway. The final product of /3-oxidation in this case is the 3-carbon pro-pionyl-CoA instead of acetyl-CoA. Three specialized enzymes then carry out the reactions that convert propionyl-CoA to succinyl-CoA, a TCA cycle intermediate. (Because propionyl-CoA is a degradation product of methionine, valine, and isoleucine, this sequence of reactions is also important in amino acid catabolism, as we shall see in Chapter 26.) The pathway involves an initial carboxylation at the a-carbon of propionyl-CoA to produce D-methylmalonyl-CoA (Figure 24.19). The reaction is catalyzed by a biotin-dependent enzyme, propionyl-CoA carboxylase. The mechanism involves ATP-driven carboxylation of biotin at Nj, followed by nucleophilic attack by the a-carbanion of propi-onyl-CoA in a stereo-specific manner. 

---