Oligosaccharides receptors

To better understand the critical role of oligosaccharide-receptor interactions and their molecular mechanisms through the cluster-effect, and thus access optimized synthetic ligands, several research groups have shown creativity in proposing original multivalent platforms that could allow for tailored valencies, dimensions, and epitope orientations. 

Oligosaccharides containing 5-thiopyranosyl units are potentially resistant to hydrolysis by exo or endo glycosidases and constitute tools to investigate oligosaccharide-receptor interactions. 

Haataja S, Tikkanen K, Nilsson U et al. (1994) Oligosaccharide-receptor interaction of the Gal alpha l lGal binding adhesin of Streptococcus suis. Combining site architecture and characterization of two variant adhesin specificities. J Biol Chem 269 27466-27472... 

Adhesion to the digestive tract wall to prevent colonisation by pathogenic microorganisms Detrimental bacteria, such as E. coli, need to become attached to the gut waU to exert their harmful effects. Attachment is achieved by means of hairlike structures, called fimbriae, on the bacterial surface. The fimbriae are made up of proteins, called lectins, which recognise and selectively combine with specific oligosaccharide receptor sites on the gut wall. Lactobacilli successfully compete for these attachment sites, as shown in Fig. 24.1. 

Polymers bearing pendant oligosaccharide groups have also been investigated as possible sequestrants for C. difficile toxins (72,73). This approach is based on the principle that toxin A has shown a lectin-like activity, which allows it to bind to an oligosaccharide receptor on epithelial cells. Fmthermore, toxin B has... 

A. Pal, sugar-binding boronic acids,ary of Peptidyl Bis (Boroxoles) as Oligosaccharide Receptors in Water Identification of a Receptor for the Tumor Marker TF-Antigen Disaccharide, Angew. Chem., Int. Ed., 2010, 49(8), 1492-1495. 

Stehle T, Yan Y, Benjamin TL, Harrison SC (1994) Structure of murine polyomavirus complexed with an oligosaccharide receptor fragment Nature 369 160-163... 

Lingwood, C. A., Oligosaccharide receptors for bacteria a view to a kill, Curr Biol, 1998, 2 695-700. 

Lodish, H. F., 1991. Recognition of complex oligosaccharides by die mnl-tisnbnnit asialoglycoprotein receptor. Trends in Biochemical Sciences 16 374-2T11. 

Yamaguchi T. Ito Y. Shibuya N.(2000) Oligosaccharide elicitors and their receptors for plant defence responses / / Tr. Glycisci. Glykotech. V. 12. P. 113-120. 

Bryant The work published on the mammalian insulin receptor shows that glycosylation is required for function. There is a mutagenesis study showing that there is a particular Asp residue, without which the receptor is expressed on the membrane but doesn t function (Leconte et al 1994). In other studies the biosynthesis of the oligosaccharides has been inhibited, and this has the same kind of effect (Podskalny et al 1984). 

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