Selection of Candidates

In order to verify performance of a given toller with whom a company has worked before, it is essential to document and understand their performance history in the five areas listed above. Good documentation of prior toller performance will allow a new engineer or new manager in charge of tolling projects to base their initial selection of candidates on accurate data. 

A data plot, as displayed in Fig. 4-15, may then constitute a useful support for the simple selection of candidate CSPs that should be available in a laboratory. For purposes of comparison, luminance data were scaled by normalizing the data in the range [0,100] by means of the following equation ... 

Pharmaceutical drug development of small molecules is initially based on the selection of candidate targets - mainly enzymes, receptors or circulating proteins that are currently targeted by 45, 28 and 11% of marketed compounds, respec-... 

The results provide the basis for comparison and selection of candidate materials based on accelerated testing, and could be used for life prediction. 

The primary selection of candidates was based on the inhibition efficiency. It was chosen to use two different experimental assays for testing the efficiency of the candidate inhibitors ... 

Finally, the 3D-LogP descriptor may be used for the 3D screening of virtual molecular conformation libraries wherein the selection of candidate molecules might not only be driven by pharmacophoric but also by physicochemical constraints. Similarly, we anticipate that the 3D-LogP descriptor will also become useful for the design of chemical libraries in which the description of the conformational space is taken into account in the description of the constituent molecules. We are currently enhancing the descriptor by implementing the last atom type classification system proposed by Wildman and Crippen (54). 

The focus of the present volume by Bernard Faller and Laszlo Urban is on methods and processes designed to predict drug-like properties, exposure and safety during hit and lead discovery. Distinguished authors from industry and academia discuss the current methods to generate pharmacokinetic and safety profiles of drug candidates, as well as how they must be balanced against one other for the best selection of candidates for further development. 

Fig. 5. Selection of candidate genes for selection in a either a study examining the role of pharmacogenomics in drug disposition and/or action or alternatively, use as a chnical tool to individualize drug therapy. Those genes prioritized for inclusion should he those shown to contribute markedly to drug pharmacokinetics and/or dynamics.

Selection of Candidate Processes or Operations Within the Firm... 

This step entails the selection of candidate processes or operations within the firm that warrant special attention. The discovery of where the process could benefit from the adoption of 1ST is the outcome of an Inherent Safety Opportunity Audit done within this and the next tasks. The criteria for identifying these include three categories (a) general safety information, (b) symptoms of inherent unsafety, and (c) inefficiency of safety management. 

Step 3 - Selection of candidate subproblem Select one of the subproblems in the candidate list to become the current candidate subproblem (CS). 

Lee SW, Tomasetto C, Sager R. 1991. Positive selection of candidate tumor-suppressor genes by subtractive hybridization. Proc Natl Acad Sci USA 88(7) 2825-2829. 

Classification into groups with acceptable/unacceptable properties Selection of candidates for synthesis Generation of in-house rules or refinement of existing screens for acceptable limits for pharmacokinetic parameters Lead generation Library design... 

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