Cancer tumor morphology

As experts in tissue engineering are aware for the reasons mentioned above, bioreactors are especially adept at producing 3D tissues that more closely resemble their normal or cancerous tissue counterparts. Specifically with respect to cancer, RWV bioreactors using prostate or melanoma cell lines can elicit 3D structures bearing close resemblance to in vivo tumor morphology. That bioreactors promise to... 

The assignment of a lesion into one of these types is purely morphological and based on the anatomical location of the tumor or the best estimate of its epicenter for those with advanced disease. Classification can be performed easily based on a combination of contrast radiography, upper endoscopy, and CT (38). In a retrospective analysis of 74 patients with gastric cancer, the preoperative classification had a high correlation (95%) to the final classification based on the resected specimen (39). 

Albert, R.E., Phillips, M.E., Bennett P., Burns, F., and Heimbach. R. (1969). The morphology and growth characteristics of radiation-induced epithelial skin tumors in the rat, Cancer Res. 29,658. 

Shain, S.A., McCullough, B and Nitchuk, W.M. (1979). "Primary and transplantable adenocarcinomas of the AxC rat ventral prostate morphologic characterization and examination of Cu-steroid metabolism by early passage tumors, J. Natl. Cancer Inst. 62,313. 

Nauss, K.M., Locniskar. M., Pavlina, T. Newbeme, PM. (1984) Morphology and distribution of 1,2-dimethylhydrazine dihydrochloride-induced colon tumors and their relationship to gut-associated lymphoid tissue in the rat. J. natl Cancer Inst., 73, 915-924... 

Most human cancerous cells evolve from the single clone of a malignant cell. As a tumor grows, significant mutation takes place, producing cells that exhibit diversified morphological and biochemical characteristics. 

Yilmaz A, Bieler G, Spertini O, Lejeune FL, Ruegg C. Pulse treatment of human vascular endothelial cells with high doses of tumor necrosis factor and interferon-gamma results in simultaneous synergistic and reversible effects on proliferation and morphology. Int J Cancer 1998 77 592-599. 

Crissman, J. D., Hatfield, J., Menter, D. J., Sloane, B. F. and Honn, K. V. (1988). Morphological study of the interaction of intravascular tumor cells with endothelial cells and subendothelial matrix. Cancer Res. 48, 4065-4072. 

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