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Cancer tumor hypoxia

Airley R, Loncaster J, Davidson S et al (2001) Glucose transporter glut-1 expression correlates with tumor hypoxia and predicts metastasis-free survival in advanced carcinoma of the cervix. Clin Cancer Res 7 928-934... [Pg.266]

The equally intriguing phenomenon of tumor hypoxia has been documented to occur in a number of tumor types including cancers of the uterine cervix (12,13), head and... [Pg.6]

Hockel M, Vaupel P. Tumor hypoxia definitions and current clinical, biologic, and molecular aspects. J Natl Cancer Inst 2001 Feb 21 93(4) 266-276. [Pg.19]

F. Dehdashti, M.A. Mintun, J.S. Lewis, J. Bradley, R. Govindan, R. Laforest, M. J. Welch, B.A. Siegel, In vivo assessment of tumor hypoxia in lung cancer with 60CU-ATSM, Eur. J. Nucl. Med. Mol. Imaging 30(6) (2003) 844-850. [Pg.191]

M. Souvatzoglou, A.L. Grosu, B. Roper, B.J. Krause, R. Beck, G. Reischl, M. Picchio, H.J. Machulla, H.J. Wester, M. Piert, Tumor hypoxia imaging with [18F] FAZAPET in head and neck cancer patients A pilot study, Eur. J. Nucl. Med. Mol. Imaging 34(10) (2007) 1566-1575. [Pg.196]

F. Dehdashti, P.W. Grigsby, M.A. Mintun, J.S. Lewis, B.A. Siegel, M.J. Welch, Assessing tumor hypoxia in cervical cancer by positron emission tomography with eOCu-ATSM Relationship to therapeutic response-a preliminary report, Int. J. Radiat. Oncol. Biol. Phys. 55 (2003) 1233-1238. [Pg.272]

B.M. Seddon, G.S. Payne, L. Simmons, R. Ruddle, R. Grimshaw, S. Tan, A. Turner, F. Raynaud, G. Flalbert, M.O. Leach, I. Judson, P. Workman, A phase I study of SR-4554 via intravenous administration for noninvasive investigation of tumor hypoxia by magnetic resonance spectroscopy in patients with malignancy, Clin. Cancer Res. [Pg.272]

Sitkovsky MV, Kjaergaard J, Lukashev D, Ohta A (2008a) Hypoxia-adenosinergic immunosuppression tumor protection by T regulatory cells and cancerous tissue hypoxia. Clin Cancer Res 14(19) 5947-5952... [Pg.255]

There is another important aspect of DNA damages. A unique feature of many cancerous tumors is the existence of hypoxic regions, that is, regions of oxygen-poor cells (J.M. Brown 1999). Such cells are often resistant to more conventional forms of antitumor treatment, such as radiotherapy and chemotherapy (Denny Wilson 2000). There has been considerable effort to identify potential antitumor drugs that specifically target such cells. One such class of potential hypoxia-specific drugs is the benzotriazine A, A -dioxides, of... [Pg.189]

I n vivo evaluation of [ Fjfluoroetanidazole as a new marker for imaging tumor hypoxia with positron emission tomography. Br. J. Cancer, 90 2232-2242, 2004. [Pg.1270]

B.W. Henderson, V. Fingar (1987). Relationship of tumor hypoxia and response to photodynamic treatment in an experimental mouse tumor. Cancer Res., 47, 3110-3114. [Pg.17]

Kizaka-Kondoh S, Inoue M, Harada H, Hiraoka M. Tumor hypoxia a target for selective cancer therapy. Cancer Sci 2003 94 1021-1028. [Pg.317]

Several reviews have highlighted the benefit of targeting tumor hypoxia, generally, and the HIF-1 pathway, specifically, in treating solid tumors [13, 77, 189]. Therefore, I will focus on those pathways and inhibitors that have been tested in vitro in breast cancer cell lines, that have been tested for efficacy in animal models of cancer, or that have been used successfully in clinical trials to treat solid tumors. [Pg.541]

Brown JM. Tumor hypoxia in cancer therapy. Methods Enzymol 2007 435 297-321. [Pg.546]

Rischin D, Hicks RJ etal. (2006) Prognostic significance of [18F]-misonidazole positron emission tomography-detected tumor hypoxia in patients with advanced head and neck cancer randomly assigned to chemoradiation with or without tirapazamine a substudy of Trans-Tasman Radiation Oncology Group Study 98.02. J Clin Oncol 24(13) 2098-2104... [Pg.50]

Table 4.4. Pretherapeutic oxygenation status of primary, locally advanced cancer of the uterine cervix and prognostic significance of tumor hypoxia (n = number of patients)... Table 4.4. Pretherapeutic oxygenation status of primary, locally advanced cancer of the uterine cervix and prognostic significance of tumor hypoxia (n = number of patients)...
No convincing data on the prognostic significance of tumor hypoxia in breast cancers available so far General anesthesia, inspiratory O2 concentration = 30%... [Pg.68]

Bristow RG, Hill RP (2008) Hypoxia, DNA repair and genetic instability. Nat Rev Cancer 8 180-192 Brizel DM (1999) Human tumor oxygenation The Duke University Medical Center Experience. In Vaupel P, Kelleher DK (eds) Tumor hypoxia. Wissenschaftliche Verlagsgesell-schaft, Stuttgart, pp 29-38... [Pg.84]

Fyles A, Milosevic M, Hedley D, Pintilie M, Levin W, Manchul L, Hill RP (2002) Tumor hypoxia has independent predictor impact only in patients with node-negative cervix cancer. J Clin Oncol 20 680-687... [Pg.85]

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See also in sourсe #XX -- [ Pg.457 , Pg.458 ]



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