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Cancer Stroma

Fig. 1. Combined miR-21 ISFI and sm-a-actin IFIC for delineation of the cellular origin of mlR-21 in breast cancer. MiR-21 was detected with TSA-FITC substrate greerf) and sm-a-actin with Cy3 redj. Section was counter stained with DAPi (Woe). The MiR-21 ISFI signal is seen in sm-a-actin-positive myofibroblast located in the breast cancer stroma (St) surrounding clusters of miR-21 negative cancer cells (Ca). The individual fluorophores are shown in blackand white. Fig. 1. Combined miR-21 ISFI and sm-a-actin IFIC for delineation of the cellular origin of mlR-21 in breast cancer. MiR-21 was detected with TSA-FITC substrate greerf) and sm-a-actin with Cy3 redj. Section was counter stained with DAPi (Woe). The MiR-21 ISFI signal is seen in sm-a-actin-positive myofibroblast located in the breast cancer stroma (St) surrounding clusters of miR-21 negative cancer cells (Ca). The individual fluorophores are shown in blackand white.
Sugiyama, Y., Farrow, B., Murillo, C., Li, J., Watanabe, H., Sugiyama, K. and Evers, B.M. (2005) Analysis of differential gene expression patterns in colon cancer and cancer stroma using microdissected tissues. Gastroenterology, 128 (2), 480—486. [Pg.271]

Ng MR, Brugge JS (2009) A stiff blow from the stroma collagen crosslinking drives tumor progression. Cancer Cell 16 455 57... [Pg.248]

Rask L, Balslev E, Jorgensen S et al (2011) High expression of miR-21 in tumor stroma correlates with increased cancer cell proliferation in human breast cancer. APMIS 119 663-673... [Pg.365]

Nielsen BS, Jorgensen S, Fog JU et al (2011) High levels of microRNA-21 in the stroma of colorectal cancers predict short disease-fi ee smvival in stage 11 colon cancer patients. Clin Exp Metastasis 28 27-38... [Pg.365]

The 5, 8-cyclonucleosides are now recognized as significant oxidative lesions that are chemically stable and form in mammalian DNA in vivo. In pig liver DNA, the levels of (5 5)-5, 8-cyclo-dA ( 0.7 lesions/10 DNA bases) were approximately four-to seven-fold lower than the levels of 8-oxo-dG, but were approximately three-fold higher than levels of 8-oxo-dA. Elevated levels of (5 S)-5, 8-cyclo-dA have also been observed in the breast connective tissue stroma of women between 33 and 46 years of age, which correlates with the known sharp increase in breast cancer incidence for women of this age group. [Pg.195]

Ip, M.M., Masso-Welch, P.A., Ip, C. 2003. Prevention of mammary cancer with conjugated linoleic acid Role of the stroma and epithelium. J. Mammary Gland Biol. Neoplasia. 8, 103-118. [Pg.129]

De Wever, O. and Mareel, M. (2003) Role of tissue stroma in cancer cell invasion. The Journal of Pathology, 200 (4), 429-447. [Pg.270]

Mueller, M.M. and Fusenig, N.E. (2004) Friends or foes — bipolar effects of the tumour stroma in cancer. Nature Reviews. Cancer, 4 (11), 839-849. [Pg.271]

Micke, P. and Ostman, A. (2004) Tumour-stroma interaction cancer-associated fibroblasts as novel, targets in anti-cancer therapy Lung Cancer 45 (Suppl. 2), S163-S175. [Pg.271]

Le, N. H., Franken, P., and Fodde, R. (2008). Tumour-stroma interactions in colorectal cancer Converging on beta-catenin activation and cancer sternness. Br J Cancer 98(12), 1886-1893. [Pg.161]

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