Cancer galectins

S. Akahani, P. Nangia-Makker, H. Inohara, H.-R. Kim, and A. Raz, Galectin-3 A novel antiapoptotic molecule with a functional BH1 (NHGR) domain of bcl-2 family, Cancer Res., 57 (1997) 5272-5276. 

L.-G. Yu, N. Andrews, Z. Zhao, D. McKean, J. F. Williams, L. J. Connor, O. V. Gerasimenko, J. Hilkens, J. Hirabayashi, K. Kasai, and J. M. Rhodes, Galectin-3 interaction with thomsen-friedenreich disaccharide on cancer-associated MUC1 causes increased cancer cell endothelial adhesion, /. Biol. Chem., 282 (2007) 773-781. 

The down-regulated proteins in HCC tissues have been identified. Park et al. identified aldehyde dehydrogenase 2 (25) and ferritin light chain (32). Kim et al. identified HSP 27, cathepsin D, and others (26). Lim et al. identified cytochrome B5, liver car-boxyesterase, and others (27). Li et al. identified SOD 1, aldolase B, and others (28). Fujii et al. identified galectin-1 (29). Kim et al. identified argininosuccinate synthase, carbamoyl-phosphate s mthase, and others (31). Table 1 shows the summary of the proteins whose expression was different between HCC cancer tissues and non-cancerous tissues. 

Ohannesian, D.W., et al. 1994. Concomitant increases in galectin-1 and its glycoconjugate ligands (carcinoembryonic antigen, lamp-1, and lamp-2) in cultured human colon carcinoma cells by sodium butyrate. Cancer Res 54 5992. 

Orlandi F, Saggiorato E, Pivano G, et al. Galectin-3 is a pre-strrgical marker of htrman thyroid carcinoma. Cancer Res. 1998 58 3015-3020. 

Thijssen VL, Poirier F, Baum LG, Griffioen AW (2007) Galectins in the tumor endothelium opportunities for combined cancer therapy. Blood 110 2819-2827... 

Colon cancer Hyaluronate receptor CD44 and RHAMM Galectins 1 et 3 Galectin 8 [135-138] [126]... 

Danguy A, Camby I, Kiss R (2002). Galectins and cancer. Biochim. Biophys. Acta. 1572 285-293. 

Poirier, F., Boutin, P., Bladier, D., Jouhert-Caron, R., and Caron, M., 2001a, Effect of 5-azac)hidine and galectin-1 on growth and differentiation of the human B l miphoma cell line bl36. Cancer Cell Int. 1 2. 

The lactulosamine structure may also act in an immunoprotective fashion, by blocking the immunosuppressive galectin-1. Thus, a divalent lactulosamine (102) restored galectin-1-impaired activity and proliferation of activated cytotoxic T-lym-phocytes in vitro, and enhanced the efficiency of dendritic-cell immunotherapy in a rodent model of breast cancer." ... 

V. V. Glinsky, G. Kiriakova, O. V. Glinskii, V. V. Mossine, T. P. Mawhinney, J. R. Turk, A. B. Glinskii, V. H. Huxley, J. E. Price, and G. V. Glinsky, Synthetic galectin-3 inhibitor increases metastatic cancer cell sensitivity to Taxol-induced apoptosis in vitro and in vivo. Neoplasia, 11 (2009) 901—909. 

Chang, Y Sasak, V. Composition and uses of galectin antagonists to augment treatment of cancer or other prohferative disorders. PCX Int. Appl. WO 2004091634, 2004 Chem. Abstr. 2004, 141, 374704. 

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