Cancer combination therapy

The benzodiazepine, lorazepam, acts allosterically on GABAa receptors to facilitate the actions of GABA. Lorazepam has some antiemetic activity in cancer chemotherapy. When used in combination therapy, it does not appear to add to antiemetic control but may contribute to a reduction in anxiety. 

Hodgkin s disease, lymphocytic lymphoma, histiocytic lymphoma, mycosis fungoides, testicular cancer, Kaposi s sarcoma, breast cancer Acute leukemia, combination therapy for various cancers... 

Combination therapy Nausea, vomiting, diarrhea, in patients with Dukes stomatitis, anorexia stage C colon cancer... 

Ohlfest, J.R., Freese, A.B., and Largaespada, D.A. 2005. Nonviral vectors for cancer gene therapy prospects for integrating vectors and combination therapies. Current Gene Therapy 5(6), 629-641. 

Chen TC,SuS, FryD,Liebes L (2003) Combination therapy with irinotecan and protein kinase C inhibitors in malignant glioma. Cancer 97 2363-2373... 

O Shaughnessy, J. et al., Superior survival with capecitabine plus docetaxel combination therapy in anthracycline-pretreated paEents with advanced breast cancer phase III trial results, J. Clin. Oncol, 20, 2812-2823, 2002. 

Carter, W.H., Jr., and Wampler, G.L. (1986), Review of the Application of Response Surface Methodology in the Combination Therapy of Cancer, Cancer Treatment Reports, 70, 133-140. 

Venturelli, S., Armeanu, S., Pathil, A., Hsieh, C.J., Weiss, T.S., Vonthein, R., Wehrmann, M., Gregor, M., Lauer, U.M. and Bitzer, M. (2007) Epigenetic combination therapy as a tumor-selective treatment approach for hepatocellular carcinoma. Cancer, 109, 2132-2141. 

In a classic case of serendipity, cisplatin (PLATINOL ), a key component of the combination therapy which revolutionised treatment of testicular cancer [ 1 ], was uncovered fortuitously in the 1960s during studies on the effect of an electric current on the growth of E. coli [ 17,18]. Cell division was inhibited not by the electric current but by production of a platinum complex from the... 

Etoposide is used for germinogenic tumors, ovarian, stomach, and lung cancer, Hodgkin s disease, and non-Hodgkin s lymphoma for both monotherapy and in combination therapy. Synonyms of this drug are vepesid and others. 

Hormonal drags do not cure cancer, although they do exhibit pronounced palliative action, with the exception of the cytotoxic action of glucocorticoids on lymphoid cells. In particular, this concerns predinsone, which is used to treat lymphomas and certain leukemias in combination therapy. 

Nigro ND, Vaitkevicius VK, Considine B Jr. Combined therapy for cancer of the anal canal a preliminary report. Dis Colon Rectum 1974 17(3) 354—356. 

Takeda et al. (64) performed a phase I/II study consisting of low-dose CDDP (6-10 mg/m2/d) and UFT (600 mg/d) combined with radiotherapy (50 Gy/25 fractions) as postoperative adjuvant therapy following curative resection for patients with nonsmallcell lung cancer (NSCLC). The combined therapy was well tolerated and resulted in a disease-free survival rate of 78% at 2 yr. Another study in a small number of patients with unresectable stage III nonsmall-cell lung cancer, UFT (400 mg/m2 on d 1-52) and CDDP (80 mg/m2 on d 8,29, and 50) were administered with radiation therapy (total dose of 60.8 Gy in 38 fractions on d 1-52). Among 17 evaluable patients, 94% (16 patients) achieved partial responses with median time to tumor progression of 30 wk, and the... 

Greenhalgh DA, Parish JH. Effect of 5-fluorouracil combination therapy on RNA processing in human colonic carcinoma cells. BrJ Cancer 1990 61 415 -19. 

Takahashi H, Yao K, Sawaki S, Kubota A, Tsukuda M, MiyakeH, Horiuchi M, Takeyama I, Kikuchihara M, Kubota T, et al. Investigation of UFT and radiation combination therapy of head and neck cancer mainly in laryngeal cancer. Gan To Kagaku Ryoho 1990 17 2037-2042. 

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