Cluster 2 Prostate Cancer

It is most probable that the causative agent for prostate cancer in leather tannery workers is a mixture of unknown composition. Working in the leather tanning industry is more commonly associated with increased prevalence of testicular cancer clusters. 7375 This is discussed in Chapter 34. 

Cluster 1 Childhood Leukemia 468 Cluster 2 Prostate Cancer 468 Clusters 3-6 Testicular Cancer 469 Cluster 7 Brain Cancer Cluster—Electronic Workers 469 Cluster 8 Brain Cancer Cluster—Petrochemical Workers 470 Cluster 9 Brain Cancers in Offspring of Electronic Workers 470 Cluster 10 Kidney Cancer Cluster 471 Cluster 11 Colorectal Cancer Cluster 471 Cluster 12 Multiple Cancer Cluster 471 Cluster 13 Lung Cancer Cluster 472 Cluster 14 Childhood Leukemia 472 Cluster 15 Multiple Cancer Clusters 473 Cluster 16 Toxic Waste Disposal Site-Related Clusters 474... 

Kuduk, S., Schwarz, J., Chen, X.-T., et al. (1998) Synthetic and immunological studies on clustered modes of mucin-related Tn and TF G-linked antigens The preparation of a glycopeptide-based vaccine for clinical trials against prostate cancer. /. Am. Chem. Soc. 120,12474-12485. 

A cluster of prostate cancer deaths was reported among a group of oil refinery workers. These workers used a mixture of chemicals to remove wax from crude oil in a lubricating oil manufacturing processJ5 The chemicals used included... 

Carter and colleagues have demonstrated that familial clustering of prostate cancer can be explained by Mendelian inheritance of a rare autosomal dominant allele, which accounts for 9% of aU prostate cancer and 45% of disease reported in men under the age of 55. Genome-wide scans have identified potential prostate cancer susceptibility loci on chromosomes 1, 2q, 12p, 15q, 16p, and 16q however. 

Tibshirani, R., Hastie, T., Eisen, M., Ross, D., Botstein, D., and Brown, P. (1999). Clustering methods for the analysis of DNA microanay data. Available http //www-stat.stanford.edu/ tibs/ftp/jcgs.ps. Tomlins, S. A., et al. (2005). Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer. Science, 28 310(5748) 644-648. 

Ishteiwy RA, Ward TM, Dykxhoom DM, Bumstein KL. The microRNA-23b/-27b cluster suppresses the metastatic phenotype of castration-resistant prostate cancer cell. PLoS One. 2012 7(12)e52106. doi 10.1371/joumal.pone.0052106. 

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