Cancer chemosensitization

Huang Y, Anderle P, Bussey KJ, Barbacioru C, Shankavaram U, Dai Z, Reinhold WC, Papp A, Weinstein JN, Sadfe W. Membrane transporters and channels Role of the transportome in cancer chemosensitivity and chemoresistance. Cancer Res 2004 64 4294-301. 

Huang, Y Anderle, P., Bussey, K.J., Barbacioru, C., Shankavaram, U., Dai, Z., Reinhold, W.C., Papp, A., Weinstein, J.N. and Sadee, W. (2004) Membrane transporters and channels role of the transportome in cancer chemosensitivity and chemoresistance. Cancer Research,... 

Chen, S.Z., Jiang, M. and Zhen, Y.S. (2005) HERG K+ channel expression-related chemosensitivity in cancer cells and its modulation by erythromycin. Cancer Chemotherapy and Pharmacology, 56, 212-220. 

Carmichael J, DeGraff WG, Gazdar AF et al. (1987) Evaluation of a tetrazolium-based semiauto-mated colorimetric assay assessment of chemosensitivity testing. Cancer Res. 47 936-942. 

Cyclopamine also interferes with cholesterol metabolism that results in decreased cholesterol synthesis and the accumulation of late biosynthetic intermediates. Cyclopamine was evaluated as an inhibitor of multi-drug resistance in tumor cells. Intrinsic or acquired resistance of tumor cells to cytotoxic drugs is a major cause of failure of chemotherapy. Both cyclopamine and the spirosolane alkaloid tomatidine from tomatoes act as potent and elfective chemosensitizers in multidrug-resistant cells (Lavie et ah, 2001). Therefore, plant steroidal alkaloids, such as cyclopamine and tomatidine, or their analogs, may serve as chemosensitizers in combination with chemotherapy and conventional cytotoxic drugs for treating multidrug-resistant cancers. 

Hon J, Wang D, Zhang R, Wang H. (2008) Experimental therapy of hepatoma with artemisinin and its derivatives In vitro an in vivo activity, chemosensitization, and mechanisms of action. Clin Cancer Res 14 5519-5530. 

Zhou J, Ong CN, Hur GM, Shen HM. (2010) Inhibition of the JAK-STAT3 pathway by andrographolide enhances chemosensitivity of cancer cells to doxorubicin. Biochem Pharmacol 79 1242-1250. 

Beltran PJ, Fan D, Fidler IJ, O Brian CA (1997) Chemosensitization of cancer cells by the staurosporine derivative CGP 41251 in association with decreased P-glycoprotein phosphorylation. Biochem Pharmacol 53 245-247... 

Whitehurst AW, Bodemann BO, Cardenas J et al (2007) Synthetic lethal screen identification of chemosensitizer loci in cancer cells. Nature 446 815-819... 

Pegram MD, Lipton A, Hayes DF, et al. Phase II study of receptor-enhanced chemosensitivity using recombinant humanized anti-pl 85HER2/neu monoclonal antibody plus cisplatin in patients with HER2/ neu-overexpressing metastatic breast cancer refractory to chemotherapy treatment. J Clin Oncol 1998 16 2659-2671. 

Osaki S, Nakanishi Y, Takayama K, Pei XH, Ueno H, Hara N. Alteration of drug chemosensitivity caused by the adenovirus-mediated transfer of the wild-type p53 gene in human lung cancer cells. Cancer Gene Ther 2000 7 300-307. 

A key question that cannot be answered using cell culture assays is whether dietary GAs can have similar effects. Importantly, evidence that dietary tomatine is effective against cancer was shown in a feeding study using rainbow trout, in which reduced tumor incidence was found in tomatine-fed trout (Friedman et al., 2007). Tomatidine has potential as a chemosensitizing... 

Isshi K, Sakuyama T, Gen T et al. Predicting 5-FU sensitivity using human colorectal cancer specimens comparison of tumor dihydropyrimidine dehydrogenase and orotate phosphoribosyl transferase activities with in vitro chemosensitivity to 5-FU. Int J Clin Oncol 2002 7 335-342. 

Sohn KJ, Croxford R, Yates Z et al. Effect of the methylenetetrahydrofolate reductase C677T polymorphism on chemosensitivity of colon and breast cancer cells to 5-fluorouracil and methotrexate. J... 

Tassone P, Tagliaferri P, Perricelli A et al. BRCAl expression modulates chemosensitivity of BRCA 1-defective HCC1937 human breast cancer cells. BrJCawcer 2003 88 1285-1291. 

Matsuyama R, Togo S, Shimizu D et al. Predicting 5-fluorouracil chemosensitivity of liver metastases from eoloreetal eaneer using primary tumor specimens three-gene expression model predicts clinical response. Int J Cancer 2006 19 406-413. 

Okumura K, Shiomi H, Mekata E et al. Correlation between chemosensitivity and mRNA expression level of 5-fluorouraeil-related metabolic enzymes during liver metastasis of colorectal cancer. Oncol Re 2006 15 875-882. 

Key Words Breast cancer prognosis transcriptional profiling proteomic profiling tissue array chemosensitivity prediction... 

In this study, a machine learning model system was developed to classify cell line chemosensitivity exclusively based on proteomic profiling. Using reverse-phase protein lysate microarrays, protein expression levels were measured by 52 antibodies in a panel of 60 human cancer cell (NCI-60) lines. The model system combined several well-known algorithms, including Random forests, Relief, and the nearest neighbor methods, to construct the protein expression-based chemosensitivity classifiers. 

Kobayashi H, Higashiyama M, Minamigawa K, et al. Examination of in vitro chemosensitivity test using collagen gel droplet culture method with colorimetric endpoint quantification. Jpn. J. Cancer Res. 2001 92 203-210. 

If accurate determination of chemosensitivity were predictable by gene expression analysis, the overall number of patients receiving cytotoxic treatment unnecessarily would decrease, and the overall survival benefit derived per patient treated would increase accordingly. Large increases in the absolute survival of patients diagnosed with breast cancer, however, will require the development of novel therapeutic agents. 

Dalton WS, Crowley JJ, Salmon SS, et al. A phase HI randomized study of oral verapamil as a chemosensitizer to reverse drug resistance in patients with refractory myeloma. A Southwest Oncology Group study. Cancer 1995 75(3) 815-820. 

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