Camptosar

Camptosar ) the covalently bound DNA topoisomerase enzyme and interferes with the DNA breakage-resealing process. Early and late diarrhea Additional toxicities Neutropenia, nausea, and vomiting... 

Irinotecan (Camptosar ) is a topoisomerase I inhibitor that forms a complex with the covalently bound DNA topoisomerase... 

Invader UGTIAI molecular assay for irinotecan toxicity. A genetic test for an increased risk of toxicity from the cancer chemotherapy drug irinotecan (Camptosar). Med Lett Drugs Ther. 48, 39-40. 

Imatinib (Gleevec) Irinotecan (Camptosar) Lapatinib (Tykerb) Letrozole (Femara) Leucovorin (Wellcovorin) Mitoxantrone (Novantrone) Paclitaxel (Taxol, Abraxane)... 

VM-26, 2), Taxol (paclitaxel), navelbine (Vinorelbine), taxotere (Docetaxel), topotecan (Hycamtin), and irinotecan (Camptosar). The last three drugs were approved by the Food and Drug Administration in 1996. 

Irinotecan Camptosar Colorectal cancer Blood disorders (anemia, leukopenia, neutropenia] dyspnea Gl distress (nausea, vomiting, diarrhea, constipation, loss of appetite, abdominal cramps]... 

H.M. Dodds, J. Robert, L.P. Rivory, The detection of photodegradation products of irinotecan (CPT-11, Campto(R), Camptosar(R)), in clinical studies, using LC-APCI-MS, J. Pharm. Biomed. Anal, 17 (1998) 785. 

Camptosar- irinotecan Leukeran - chlorambucil Targretin - bexarotene... 

Synonyms Camptothecin-1 I CPT-1 I Trade name Camptosar (Pfizer)... 

A few years after the introduction of Taxol in 1996, further phytogenic anticancer drugs were launched to treat advanced cancers. Topotecan, marketed by Smith Kline Beecham under the trade name of Hycamtin, was approved by the FDA to treat ovarian cancers that have resisted other chemotherapy drugs. Furthermore, irinotecan was introduced by Pharmacia Upjohn under the trade name of Camptosar for the treatment of metastatic cancer of the colon or rectum. Both compounds are derivatives of camptothecin which was isolated from the Chinese tree Camptotheca acuminata, well known in Chinese Traditional Medicine for anticancer treatment [65]. Isolation of the bioactive principle camptothecin and its structure elucidation had already been performed in 1966... 

Irinotecan (Camptosar, CPT-11) is a camptothecin-derived topoisomer-ase I inhibitor approved by the Food and Drug Administration (FDA) for use in metastatic colorectal cancer, either as a first-line component of combined therapy, or as a second-line single-agent treatment [1]. It is also currently in clinical trials for use in various other solid tumors [2]. When... 

Topoisomerase I inhibitors Irinotecan (CPT-11 Camptosar) Colon cancer NSCLC SCLC cervical and ovarian cancers gastric cancer pancreatic cancer... 

Irinotecan (Camptosar), a more selective synthetic analogue of camptothecin (a natural, but toxic, anticancer alkaloid), acts by inhibiting topoisomerase 1, an enzyme involved in ordering the strands of DNA. Some compounds act by physical binding with vital natural polymers - the complex indole alkaloid vincristine is a classic example - it binds to tubulin, a protein essential to cell division. 

This discovery significantly increased interest in the compound and led to the synthesis of a number of water-soluble analogues, which ultimately led to the development of the camptothecin analogues topotecan (Hycamtin) (15) and irinotecan (Camptosar) (16), both of which have been approved for clinical use. Topotecan is used as second-line therapy for advanced ovarian cancer in patients who have failed to respond to treatment regimens that include platinum or paclitaxel, while irinotecan has been approved for the treatment of advanced colorectal cancer. 

Approved dosage schednles of irinotecan (Camptosar) in the United States inclnde 125 mg/m as a 90-minute infusion administered weekly for 4 ont of 6 weeks 350 mg/m given every 3 weeks 100 mg/m every week or 150 ing/m every other week. Irinotecan has sigifificant clinical activity... 

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