Quassinoids from Simaba multiflora

Several quassinoids are known to have antileukemic activity (Blasko and Cordell, 1988 Cordell, 1978 Polonsky, 1983). Only compounds with a C20 skeleton have antileukemic activity. Quassimarin (51) from Quassia amara and bruceoside A (52) from Brucea javanica and a series of other quassinoids from Brucea antidysenterica (all Simarou-baceae) (Fig. 25.12) are active in this regard. Bruceantin (53) has a high degree of antitumor activity in P-388, LE, LL and B16 tissue culture systems (Cordell, 1978). Six quassinoids from Simaba multiflora and Soulamea soulameoides were shown to be active against several mmor systems (Klocke et al., 1985). 

Arisawa M, Kinghorn AD, Cordell GA, Farnsworth NR 1983a Plant anticancer agents. XXIII. 6-a-Senecioyl-oxy-chaparrin, a new antileukemic quassinoid from Simaba multiflora. J Nat Prod 46 218-221... 

Arisawa, M., a. D. Kinghorn, G. A. Cordell, and N. R. Farnsworth Plant Anticancer Agents. XXIIL 6a-Senecioyloxy Chaparrin, a New Antileukemic Quassinoid from Simaba multiflora. J. Nat. Prod. 46, 218 (1983). 

Polonsky, J., J. Gallas, J. Varenne, T. Prange, C. Pascard, H. Jacquemin, and C. Moretti Isolation and Structure (X-Ray Analysis) of Karinolide, A New Quassinoid from Simaba multiflora. Tetrahedron Lett. 869 (1982). 

Quassinoids.—The structure of soulameolide (108), a new C25 quassinoid from Soulamea tomentosa, has been established by X-ray analysis.The search for biologically active compounds continues. Undulatone (109) from Hannoa undulata, 6a-tigloyloxychapparinone (110) from Ailanthus integrifoliaj and 6a-senecioylchapparinone (111) from Simaba multiflora have antileukaemic... 

A series of six quassinoids isolated from Simaba multiflora and Soulamea soulameoides were shown to be active as growth inhibitors and as antifeedants against Heliothis virescens (cotton budworm) and Spodoptera frugiperda (fall armyworm) (Klocke et al., 1985). 

Two new quassinoids, 13,18-dehydro-6a-senecioy1oxychaparrin (200) and 12-dehydro-6a-senecioyloxychaparrin (201), have been isolated from the fruits of Simaba multiflora [81],... 

Simaba orinocencis Hunth (= S. multiflora) is a native tree found in the Amazonian riversides and seasonally inundated areas of South America [83]. A new antimalarial quassinoid, namely, orinocinolide (203), was isolated from the root bark of Simaba orinocencis [83],... 

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