Brown locus

Jackson, I. J. (1988). A cDNA encoding tyrosinase-related protein maps to the brown locus in mouse. Proc. Natl. Acad. Sci. USA 85 4392-4396. 

Shibahara, S., Taguchi, H MUller, R Shibata, K., Cohen, T., Tomita, Y., and Tagami, H. (1991). Structural organization of the pigment cell-specific gene located at the brown locus in mouse. J. Biol. Chem. 24 15895-15901. 

Vijayasaradhi, S., Xu, Y., Bouchard, B., and Houghton, A. (1995). Intracellular sorting and targeting of melanosomal membrane proteins identification of signals for sorting of the human brown locus protein, gp75. J. Cell Biol. 130, 807-820. 

Large amounts of iron are sequestered in substantia nigra and in locus coerulus as a neuromelanin-iron complex in dopaminergic neurons particularly in PD. Neuromelanin, a granular dark brown pigment, is produced in catecholaminergic neurons of the SN and... 

Dinauer, M. C., Orkin, S. H., Brown, R., Jesaitis, A. J., Parkos, C. A. (1987). The glycoprotein encoded by the X-linked chronic granulomatous disease locus is a component of the neutrophil cytochrome b complex. Nature 327, 717-20. 

Doughty, S., Sloan, J., Bennett-Wood, V., Robertson, M., Robins-Brown, R. M., and Hartland, E. L. (2002). Identification of a novel fibrial gene cluster related to long polar fimbriae in locus of enterocyte effacement-negative strains of enterohemorrhagic Escherichia coli. Infect. Immun. 70, 6761-6769. 

Nicholls, L., Grant, T. H., and Robins-Browne, R. M. (2000). Identification of a novel genetic locus that is required for in vitro adhesion of a clinical isolate of enterohaemorrhagic Escherichia coli to epithelial cells. Mol. Microbiol. 35, 275-288. 

Pickering-Brown, S. (2004) The tau gene locus and frontotemporal dementia. Dement. Geriatr. Cogn. Disord., 17, 258-260. 

The R locus determines the presence (R) or absence (r) of anthocyanins in the seed coat. R is required (with i and T) to produce black seed [10]. However the identity of the gene product encoded by this locus has not been reported. Todd and Vodkin [25] have demonstrated that brown seed coats (r) contain proanthocyanidin (PAs) and black seed coats (R) contain anthocyanins in addition to PAs and suggested that R acts subsequent to the formation of leucoanthocyanidin but previous to the formation of anthocyanins. UDP-glucose flavonoid 3-0-glucosyltransferase (UF3GT) should be considered a candidate gene of the R locus but its identiflcation has not yet been reported. 

Perhaps the least understood of the five loci that control seed coat color in soybean is the O locus [10, 11]. The O locus only affects the phenotype of brown... 

Hoffman EP, Brown RH, Jr., Kunkel LM. Dystrophin the protein product of the Duchenne muscular dystrophy locus. Cell. Dec 24 1987 51(6) 919-928. 

Vermerris, W., Thompson, K. J., and McIntyre, L. M., 2002, The maize Brown midrib I locus affects cell wall composition and plant development in a dose-dependent manner, Heredity 88 450-457. 

Hobbs HH, Russell DW, Brown MS, Goldstein JL. The LDL receptor locus in familial hypercholesterolemia mutational analysis of a membrane protein. Annu Rev Genet 1990 24 133-170. 

I shall argue that this worry can be put to rest. The main reason is that the world is not constituted by beliefs. It is constituted by concepts. If it were constituted by beliefs, the worry would be justified. If the fact that the table is brown depended on there being a belief that the table is brown, there would be no room for objective facts. What there is would be completely determined by the mind. Concepts, however, do not have the power to determine that much. They can determine merely what there can be, not what actually there is. So there is a gap between what the mind fixes about the world and the world. This gap is the locus of objectivity. But we should distinguish between various cases. So I shall proceed step by step. 

Brown RM, Fraser NJ, Brown GK Differential methylation of the hypervariable locus DXS255 on active and inactive X chromosomes correlates with the expression of a human X-linked gene. Genomics 7 215-221,1990. 

McConkie-Rosell A, Lachiewicz AM, Spiridigliozzi GA, Tarleton J, Schoenwald S, Phelan MC, Goonewardena P, Ding X, Brown WT. (1993) Evidence that methylation of the FMR-I locus is responsible for variable phenotypic expression of the fragile X syndrome. Am J Hum Genet 53 800-809. 

---