3-bromo-2-methyl

Furan-2-carboxylic acid, 5-bromo-, methyl ester UV, 4, 588 <57JOC323>... 

METHYL B-BROMOVALERATE (Valeric acid, 8-bromo-, methyl ester)... 

Polystyrene bisperoxides can be prepared by the termination of polystyryl anion with bromo methyl benzoyl peroxide [9] ... 

Benzyl alcohol, a-vinyl- [Benzene-methanol, a-ethenyl-), 106 Bcnzylamine-polystyrene [Benzene, di-ethenyl-, polymer with ethenyl-benzene, aminomethylated), 95 Benzyl bromide [Benzene, (bromo-methyl)-, 78... 

In the condensation reaction between chloro- and bromo-methyl aryl sulfones and carbonyl compounds, a-sulfonyloxiranes were obtained. In this condensation reaction, bases such as potassium t-butoxides372, NaH373 and aqueous concentrated hydroxide with benzyltriethylammonium chloride under two-phase condensation were used374. In the reaction with aldehydes only the trans-epoxide isomers resulted, whereas lith-iofluoromethyl phenyl sulfone 289375 and 291376 were found to add to aldehydes affording /J-hydroxysulfones 290 and 292, respectively. 

Dimethoxy-6,7-dimethylquinoxaline gave a separable mixture of 6-bromo-methyl-2,3-dimethoxy-7-methylquinoxaline (165, R = H) and 6,7-bis(bromo-methyl)-2,3-dimethoxyquinoxaline (165, R = Br) pSfBS, BZ2O2, CCI4, reflux. 

Acetic acid, anhydride, [108-24-7], 58,157 bromo-, methyl ester [96-32-2], 57, 60 chloro-, 1,1-dimethylethyl ester, 55, 94 cyano-, ethyl ester [105-56-6], 55, 58,... 

The bromo methyl ester (212) formed by treatment of 30 with hydrogen bromide in acetic acid could also serve as a precursor to validamine. ... 

Potassium 4-chloro-3,5-dinitrobenzene-sulfonate, 31, 46 Potassium cyanate, 31, 9 Potassium cyanide, 30,84 32,31,63 37,47 Potassium ethyl malonate, 37, 34 Potassium ethyl xanthate, 30, 56 Potassium fluoride, 36, 40 Potassium iodide, 30, 34 31, 31, 66 Potassium metal, 37, 29, 30 Potassium methyl sulfate, 31, 73 Potassium nitrate, 31, 46 Potassium 1-nitropropylnitronate, 37, 24 Potassium oxalate, 34, 83 Potassium permanganate, 30, 87 31, 59 Potassium sulfide, 32, 103 Potassium thiobenzoate, 32, 101 Potassium thiocyanate, 32, 39, 40 Prins reaction, 33, 72 Propane, 1, 3-dibromo-2, 2-Ws-(bromo-methyl)-, 31, 82... 

The cycloaddition of Weinreb amide functionalized nitrile oxide with a range of dipolarophiles has been studied. N-Methoxy-N-methylcarbonocyanidic amide, nitrile oxide 207 (i.e., a nitrile oxide of Weinreb amide type derivative) was generated from 2-chloro-2-(hydroxyimino)-N-methoxy-N-methylacetamide as intermediate and used in situ. Thus, addition of 3-bromo-l-propyne as dipolarophile to this precursor of 207, followed by quenching with triethylamine, gave 5-(bromo-methyl)-N-(methoxy)-N-methyl-3-isoxazolecarboxamide 208 in 55% to 60% yield (367). 

Interest continues in the preparation and characterization of the 6/3-bromo-methyl- and 6/3-iodomethyl-cholest-5(10)-en-3/3-ols (4) and (5) respectively owing to the potential use of their radiohalogenated derivatives as adrenal scanning agents. The 6/8-bromomethyl compound (4) is conveniently prepared by... 

Bis(bromomethyl)propane-l,3-diol may enter the enviromnent as fugitive dust, through wastewater and through disposal of resins and foams which may contain the compoimd as an impurity. 2,2-Bis(bromomethyl)propane-l,3-diol may be persistent in water (Environmental Protection Agency, 1983 Elwell et al., 1989 Durmick et al., 1997). No data were available to the Working Group on levels of 2,2-bis(bromo-methyl)propane-l,3-diol in the environment. 

Table 2. Neoplastic and related lesions in rats treated with 2,2-bis(bromo-methyl)propane-l,3-diol in the diet for three months (stop-exposure) or two years...

National Toxicology Program (1996) Toxicology and Carcinogenesis Studies of 2,2-Bis(bromo-methyl)propane-l,3-diol (FR-1138 ) (CAS No. 3296-90-0) in F344/N Rats and B6C3F1 Mice (Feed Studies) (Technical Report Series No. 452 NIH Publication No. 96-3368), Research Triangle Park, NC... 

The nature and position of substituents relative to the ring oxygen atom have an important effect on the acid-catalyzed isomerization of oxepins. It has been observed that, in addition to the hydrogen isotopes ( H, 2H, 3H), chloro, bromo, methyl (72E1129) and alkoxycarbonyl (79JA2470) substituents also show the migration-retention sequence found in the NIH shift. 

I. BROMO(METHYL) (A, TV, TV, TV-TETRAMETH YLETHYLENE-DIAMINE)PALLADIUM(II)... 

Treatment of the dibromides with sodium ethoxide gives 2-bromo-methyl-2,3-dihydrobenzofurans (170) o- (2,3-dibromopropyl)phenyl acetate (188, X = OAc, R = H) gives 2-bromomethyl-2,3-dihydro-benzofuran (170, R = R1 = H).447 The following substituted 2-bromo-methyl-2,3-dihydrobenzofurans have been prepared by this method ... 

Introduction of a chlorine atom into the 1- or 3-position of the alkyl radical in l-alkylsilatranes(18, 19) decreases to some extent the average LDS0 value 2200—2800 mg/kg). However almost all 1-chloroalkylsilatranes prove to have low toxicity. Replacement of one hydrogen atom in the methyl radical of 1-methylsila-trane by a bromine or iodine atom (28, 29) as well as the replacement by two halogen atoms (31) increases markedly the toxicity of 1-halogenalkylsilatranes. In this case the animals show depression, rapid breathing, tremor. Administration of 1-bromo-methyl- (28) and 1-iodomethylsilatrane (29) causes hyperaemia, tremor and depression. 

It is widely held that protic ( acidic ) solvents favour monoalkylation of diethyl malonate carbanion, whereas aprotic ( inert ) solvents favour dialkylation. Exactly opposite results have now been obtained in the reactions of die alkali metal salts of diethyl malonate with 1,2-bis-, 1,2,4,5-tetrakis-, and 1,2,3,4,5,6-hexakis-(bromo-methyl)benzenes in ethanol and in DMSO, the former solvent preferring dialkylation (cyclization) and the latter monoalkylation.106 Other interesting related observations were made. 

Bromocyclocarbamation reaction of l-allyl-2-[( R)-menthyloxycarbo-nyl] derivatives of Reisert compounds 102 was accompanied by BrOMe addition to the C(3)-C(4) double bond to give 2-bromo-methyl-[l,3]oxazino[4,3-a]isoquinoline-4-ones 103 either under condition A with Br2 or under condition B using pyridinium tribromides (08JHC1651). 

---