1- Bromo-2-methyl propane

It is possible to obtain anti-Markovnikov products when HBr is added to alkenes in the presence of free radical initiators, e.g. hydrogen peroxide (HOOH) or alkyl peroxide (ROOR). The free radical initiators change the mechanism of addition from an electrophilic addition to a free radical addition. This change of mechanism gives rise to the anh-Markovnikov regiochemistry. For example, 2-methyl propene reacts with HBr in the presence of peroxide (ROOR) to form 1-bromo-2-methyl propane, which is an anh-Markovnikov product. Radical additions do not proceed with HCl or HI. 

Bromo-2-methyl-propane Br-CH2CH(CH3)2 70.5 295.0 Correlation 2003KRO/TUM... 

Bis(bromomethyl)propane-l,3-diol may enter the enviromnent as fugitive dust, through wastewater and through disposal of resins and foams which may contain the compoimd as an impurity. 2,2-Bis(bromomethyl)propane-l,3-diol may be persistent in water (Environmental Protection Agency, 1983 Elwell et al., 1989 Durmick et al., 1997). No data were available to the Working Group on levels of 2,2-bis(bromo-methyl)propane-l,3-diol in the environment. 

Table 2. Neoplastic and related lesions in rats treated with 2,2-bis(bromo-methyl)propane-l,3-diol in the diet for three months (stop-exposure) or two years...

National Toxicology Program (1996) Toxicology and Carcinogenesis Studies of 2,2-Bis(bromo-methyl)propane-l,3-diol (FR-1138 ) (CAS No. 3296-90-0) in F344/N Rats and B6C3F1 Mice (Feed Studies) (Technical Report Series No. 452 NIH Publication No. 96-3368), Research Triangle Park, NC... 

The reaction of 2 2 dimethyl 1 propanol with HBr is very slow and gives 2 bromo 2 methyl propane as the major product... 

Potassium 4-chloro-3,5-dinitrobenzene-sulfonate, 31, 46 Potassium cyanate, 31, 9 Potassium cyanide, 30,84 32,31,63 37,47 Potassium ethyl malonate, 37, 34 Potassium ethyl xanthate, 30, 56 Potassium fluoride, 36, 40 Potassium iodide, 30, 34 31, 31, 66 Potassium metal, 37, 29, 30 Potassium methyl sulfate, 31, 73 Potassium nitrate, 31, 46 Potassium 1-nitropropylnitronate, 37, 24 Potassium oxalate, 34, 83 Potassium permanganate, 30, 87 31, 59 Potassium sulfide, 32, 103 Potassium thiobenzoate, 32, 101 Potassium thiocyanate, 32, 39, 40 Prins reaction, 33, 72 Propane, 1, 3-dibromo-2, 2-Ws-(bromo-methyl)-, 31, 82... 

When the concentration of 2-bromo-2-methyl-propane, C4H9Br, is doubled, the rate of the reaction... 

The preparation of the Step 1 co-reagent, AI-[4-nitro-3-(trifluoromethyl)phenyl]-(2f )-3-bromo-2-hydroxy-2-methyl propan amide, (I), was previously prepared by the authors (2) and illustrated in Eq. 2. 

SYNS ACETONYL BROMIDE ACETYL METHYL BROMIDE BROMOACETONE BROMOACETONE (DOT) BROMOACETONE, Uquid (DOT) BROMO-METHYL METHYL KETONE 1-BROMO-2-PROPAN-ONE MONOBROMOACETONE RCRA WASTE NUMBER POl 7... 

Figure 16. Current decay curves the natural logarithm of the steady-state oxidation plateau current of radical anions (mediators) plotted against time (s) for the following four combinations of mediator/substrate benzophenone/l-bromo-2,2-dimethylpropane (-(-) perylene/l-bromo-2,2-dimethylpropane (x) perylene/l-bromoadamantane ( ) and quinoxaline/2-chloro-2-methyl-propane (O). All measurements were obtained with a 10-pm platinum disk electrode in DMF/0.1 M BU4NBF4 at 22°C. From S. U. Pedersen and K. Daasbjerg, Acta Chem. Scand, 43 30 (1989) [36],...

Potassium oxalate, 34, 83 Potassium permanganate, 30, 87 31,59 Potassium phthalimide, 38, 81 Potassium sulfide, 32,103 Potassium thiobenzoate, 32,101 Potassium thiocarbonate, 39, 78 Potassium thiocyanate, 32,39,40 Potassium trithiocarbonate, 39, 78 Prins reaction, 33, 72 Propane, 1, 3-dibromo-2,2-5m-(bromo-methyl)-, 31, 82... 

The mechanism for an El reaction is illustrated by the reaction of 2-bromo-2-methyl-propane to form 2-methylpropene. In this two-step mechanism, the rate-determining step is the ionization of the carbon-halogen bond to form a carbocation intermediate (just as it is in an S l mechanism). 

With the alternative combination of sodium methoxide and 2-bromo-2-methyl-propane, no ether is formed 2-methylpropene, formed by dehydrohalogenation, is the only product. 

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