Bromo acetic acid

However, the relative rates with His 12 and 119 vary widely depending on the structure of the reagent. The d antipodes generally favor reaction at His 12, the l compounds at His 119. No convincing correlation of all these facts with the X-ray structure has yet been made. In view of the fact that sulfate or phosphate ions seriously interfere with the alkylation reaction 160), the X-ray structures determined in the presence of these ions may be misleading. However, Bello and Nowoswiat have shown (69) that with RNase-A in crystalline form the alkylation with bromo-acetic acid is comparable, but not identical, to that found in dilute solution. 

Tetrabenzylcyclen 7 has been prepared in nearly quantitative yield by refluxing a mixture of 6 and p-toluenesulfonic acid in alcohol for 6 hours. Debenzyla-tion of 7 can be carried out by treatment with 10% Pd-C under hydrogen. Cyclen 4 is obtained in a high yield. Alkylation with chloro- or bromo acetic acid leads to the ligand DOTA 9 [25]. Subsequent complexation with gadolinium chloride or gadolinium oxide in the usual manner yields Gd-DOTA 5 (Scheme 3). 

HydroxyMTX (614), which is an inactive metabolite of MTX, has been prepared by condensation of 2,4-diamino-7-hydroxypteridine-6-(a-bromo)-acetic acid (613) with p-methylaminobenzoylglutamic acid hydrobromide decarboxylation takes place during the reaction to give (614) directly... 

Phenyl acetyl chloride benalaxyl, brodifacoum, difenacoum, difethialone, flocoumafen Phenyl bromo acetic acid phentoate... 

Scheme 24.1 (a) Synthesis of asymmetric cyanine dyes (A) bromo acetic acid, EtOAc (B) Mei, K2CO3, DMF (C) TosOMe,... 

Because modem anion exchangers are solvent-compatible, solvents can also be used to alter selectivity. Figure 9-17 illustrates the gradient elution of chloro-and bromo-acetic acids on lonPac AS 11 with a constant content of methanol in the mobile phase. Even though separations of this kind are promising, it is questionable whether the necessary sensitivity for water analysis can be achieved with suppressed conductivity detection. Thus, the method of IC-MS via an electrospray interface introduced by Hashimoto and Otsuki [57] creates a lot of interest. With this method the authors analyzed nine different chloro- and bromo-acetic acids at trace levels. However, the method requires analyte extraction with methyl-tert.-butyl ether. Based on a 200-mL water sample, detection... 

Bromoacetyl-N-hydroxysuccinimide Ester. To a solution of bromo-acetic acid (139 mg, 1.0 mmole) and AT-hydroxysuccinimide (115 mg, 10 mmoles) dissolved in 5 ml of dioxane is added dicyclohexylcarbodiimide (206 mg, 1.0 mmole) in 2 ml of dioxane. After 1 hr at room temperature, the dicyclohexylurea is removed by filtration and washed with dioxane. The filtrate is evaporated to dryness and crystallized from isopropanol, yield, 75% m.p., 117°. 

Synthesis of Bromoacetyl-N-hydroxysucdnimide See Fig. 1). Bromo-acetic acid (0.5 mmole, 66 mg) is dissolved in 0.6 ml of dry dioxane and 0.2 ml of dry ethyl acetate. iV-Hydroxysuccinimide, 0.6 mmole, is added, and the mixture is cooled to 4° in an ice-water bath. Dicyclohexyl-carbodiimide, 0.5 mmole, dissolved in 0.5 ml of dry dioxane at 0°, is then added to the mixture. The reaction is stirred for 1 hr in an ice-water... 

Poly(l-azabicyclo[4.2.0]octane) (polyconidine) was synthesized with bromo-acetic acid using microwave irradiation (Karabulut et al., 2008). 1-Azabicyclo[4.2.0] octane contains unsubstituted four-membeied azetidine ring. It was synthesized with microwave-assisted methods and used in cationic ring-opening polymerization as a monomer. 

CsHsBrOj bromo-acetic acid propyl ester 35223-80-4 ... 

CsHsBrOi bromo-acetic acid isopropyl ester 29921-57-1 ... 

C6HiiBr02 bromo-acetic acid butyl ester 18991-98-5... 

C6HiiBr02 bromo-acetic acid tert-butyl ester ... 

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