Acetic acid, bromo-, ethyl ester

ETHYL BROMOACETATE (Acetic acid, bromo-, ethyl ester)... 

Ethyl bromoacetate Acetic acid, bromo-, ethyl ester (8, 9) (105-36-2) Tetrabutylammonium fluoride hydrate Ammonium, tetrabutyl-, fluoride, hydrate (8) (22206-57-1)... 

Acetal formation from pentaerythritol and benzaldehyde, 38, 65 Acetamide, 31, 17 Acetamide, N-bromo, 31,17 a-PHENYL-, 32, 92 Acetanilide, cz-benzoyl-, 37, 2 a -ben zoyl-2-mcth oxy-4-ni tro, 37, 4 Acetic acid, benzoyl-, ethyl ester, 37, 3, 32... 

Acetic acid, bromo-, 2-butene-1,4-diyl ester Acetic acid, bromo-, 2-butenylene ester. See 1,4-Bis (bromoacetoxy)-2-butene Acetic acid, bromo-, diester with ethylene glycol Acetic acid, bromo-, 1,2-ethanediyl ester Acetic acid, bromo-, ethylene ester. See 1,2-Bis (bromoacetoxy) ethane Acetic acid 2-butoxy ester. See s-Butyl acetate Acetic acid, [2-[2-butoxyethoxy] ethoxy]-. See Buteth-2 carboxylic acid Acetic acid 2-(2-butoxyethoxy) ethyl ester. See Diethylene glycol butyl ether acetate Acetic acid, (2-butoxyethoxy)-, sodium salt. See Sodium butoxyethoxy acetate Acetic acid, 2-butoxyethyl ester. See Butoxyethanol acetate Acetic acid, butyl ester. See n-Butyl acetate Acetic acid 2-butyl ester. See s-Butyl acetate Acetic acid n-butyl ester. See n-Butyl acetate Acetic acid, s-butyl ester. See s-Butyl acetate Acetic acid t-butyl ester. See t-Butyl acetate Acetic acid, C7-9-branched alkyl esters, C8-rich. See C8 alkyl acetate... 

C4H7Br02 acetic acid 2-bromo-ethyl ester 927-68-4... 

This synthesis came shortly after one by Prelog, Kohlberg, Cerkovnikov, Rezek and Piantanida (1937) based on a series of reactions which, with modifications and extensions. Prelog and his colleagues have applied to the syntheses of bridged heterocyclic nuclei, of which this is an example. 4-Hydroxymethyltetrahydropyran (VI R =. OH) is converted via the bromo-compound (VI R = Br) and the nitrile (VI R = CN) into tetrahydropyran-4-acetic acid of which the ethyl ester (VII) is reduced to 4-()3-hydroxyethyl)-tetrahydropyTan (VIII). This is converted by fuming hydrobromic acid into 3-(2-bromoethyl)-l 5-dibromopentane (IX) which with ammonia in methyl alcohol yields quinuclidine (V). 

Hexadiene, 55,109 Hexanoic acid, 55, 27 28 Hexanoic acid, 2-bromo-, 55,30 Hexanoic acid, 3-oxo ethyl ester [Acetic... 

Acetic acid, anhydride, [108-24-7], 58,157 bromo-, methyl ester [96-32-2], 57, 60 chloro-, 1,1-dimethylethyl ester, 55, 94 cyano-, ethyl ester [105-56-6], 55, 58,... 

PROPENOIC ACID, 3-NITRO-, ETHYL ESTER, (E)- [5941-50-4], 56,65 2-PROPEN-l-OL, 55,1 2-BROMO-3,3-DIPHENYL-, ACETATE [14310-15-71,56, 32... 

The reaction of potassium 3-amino-4-oxo-3,4-dihydroquinazoline-2-thiolate 62 with a-bromophenylacetic acid 63 resulted in the formation of (3-amino-4-oxo-3,4-dihydroquinazolin-2-ylsulfanyl)-phenyl-acetic acid methyl ester 64 which on alkali treatment and subsequent acidification resulted in the synthesis of 2-phenyl- 1-thia-4,4a,9-triaza-anthracene-3,10-dione 65 <1999JCR(S)86>. Similarly, the reaction of potassium 3-amino-5,6-dimethyl-4-oxo-3,4,4a,7a-tetrahydrothieno[2,3- pyrimidine-2-thiolate 66 with a-bromo-ester 67 resulted in the formation of 2-(3-amino-5,6-dimethyl-4-oxo-3,4,4a,7a-tetrahydrothieno[2,3- / pyrimidin-2-ylsulfanyl)-propionic acid ethyl ester 68. Subsequent treatment with alkali followed by acidification resulted in the formation of 2,3,7-trimethyl-3a,9a-dihydro-l,8-dithia-4a,5,9-triazacyclopenta[ ]naphthalene-4,6-dione 69 <2000JHC1161>... 

The next three procedures provide useful synthetic intermediates. A stereospecific synthesis of ETHYL (Z)-3-BROMO-2-PROPENOATE affords an alternative vinyl bromide partner for the coupling chemistry in the preceding procedure. A very simple but elegant illustration of the flash vacuum pyrolysis technique is used to prepare BENZOCYCLOBUTENONE from o-toluoyl chloride. Another member of the functionalized indole family of synthetic intermediates is presented in a four-step procedure for 5-METHOXYINDOLE-2-ACETIC ACID METHYL ESTER. 

Interestingly, exchange of the iodoacrylate to the bromo derivative in 4.38. leads to a different reaction. Dimerization of two hexyne molecules and subsequent attachment of the acrylate gave 2-(2 ,3 ,4 ,5 -tetraethylcyclopentadienyl)-acetic acid ethyl ester in 74% yield.51... 

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