Bright s disease

Onanism, melancholy, and gout, unfortunately, were but way-stations on the road to final catastrophe. The uric acid deposits in a person s tissues would gradually increase in quantity as the years passed and as his constitutional vigor waned, until at last, Haig predicted, "the long pent up store of urates breaks its dams and rushes into the circulation with an overwhelming flood." If not destroyed on the rocks of apoplexy, the helpless victim would be swept onward to heart failure, Bright s disease, or a like fate. (25)... 

S. J. Peitzman, Bright s disease and Bright s generation, toward exact medicine at Guy s Hospital , Bull. Hist. Med., 1981, 55, 307-321. 

That inspectors be placed at the disposal of the Department... That the advertisement and sale (except the sale by a doctor s order) of medicines purporting to cure the following diseases be prohibited cancer, consumption, lupus, deafness, diabetes, paralysis, fits, epilepsy, locomotor ataxy, Bright s disease, rupture. 

Gl. Garrod, A. B., Observations on certain pathological conditions of the blood and urine in gout. Rheumatism and Bright s Disease. Med.-Chir. Trans. 31, 83 (1848) (as cited in Engelman et al., E6). 

Henderson DA, Inglis JA. The lead content of bone in chronic Bright s disease. Austr Ann Med 1957 6 145-154. 

Many of these tests must be performed by using sophisticated and sensitive instrumentation. However, a very simple test, the measurement of the specific gravity of urine, can be an indicator of diabetes mellitus or Bright s disease. The normal range for human urine specific gravity is 1.010-1.030. 

Blumberg sign Bouchard nodes Bright s disease Buerger s disease... 

Gingivostomatitis Inflammation of and damage to the glomeruli of the kidneys. Known also as Bright s disease. 

Tyson, J. A treatise on Bright s disease and diabetes, p. 267. Philadelphia Lindsay and Blakiston 1881. 

Frasch had been suffering for many years from Bright s disease (glomerulonephritis, an inflammation of the kidneys), which kept him at spas and health resorts in Europe. He was forced to retire because of his declining health. After a brief return to New York in April, he left for Paris in June 1912. Besides a brief visit to New York City and to Gaildorf in the summer of 1913, he stayed in Paris. 

Sulfasalazine. Salicylazosulfapyridine or Azulfadine [599-79-1] (2-hydroxy-5-[[4[(2-pyridylamino)sulfonyl]-phenyl]azo] benzoic acid) (15) is a light brownish yellow-to-bright yellow fine powder that is practically tasteless and odorless. It melts at ca 255°C with decomposition, is very slightly soluble in ethanol, is practically insoluble in water, diethyl ether, chloroform, and benzene, and is soluble in aqueous solutions of alkali hydroxides. Sulfasalazine may be made by the synthesis described in Reference 13. It is not used as an antidiarrheal as such, but is indicated for the treatment of inflammatory bowel diseases such as ulcerative colitis and Crohn s disease. Its action is purported to result from the breakdown in the colon to 5-aminosalicylic acid [89-57-6] (5-AS A) and sulfapyridine [144-83-2]. It may cause infertility in males, as well as producing idiosyncratic reactions in some patients these reactions have been attributed to the sulfa component of the compound. The mechanism of 5-ASA is attributed to inhibition of the arachidonic acid cascade preventing leukotriene B4 production and the ability to scavenge oxygen free radicals. The active component appears to be 5-aminosalicylic acid. 

Answer Some individuals with Oguchi s disease have a defective rhodopsin kinase that slows the recycling of rhodopsin after its conversion to the all-trans form on illumination. This defect leaves retinal rod and cone cells insensitive for some time after a bright flash. Other individuals have genetic defects in arrestin that prevent it from interacting with phosphorylated rhodopsin to trigger the process that leads to replacement of all-brms-retinal with 11-c/s-retina.l. 

Vestibular disorders are dizziness, unsteadiness, or imbalance when walking. Vertigo, nausea, headache, and muscular aches in the neck and back, motion sickness, and sensitivity to noise and bright lights may be mild (lasting minutes) or severe (resulting in total disability). Meniere s disease, labyrinthitis, and inner ear infections can cause vestibular disorders. Common causes of vestibular disorders follow ... 

Bright s diseasenonspecific name for degenerative kidney disease. 

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