Uric acid deposits

Onanism, melancholy, and gout, unfortunately, were but way-stations on the road to final catastrophe. The uric acid deposits in a person s tissues would gradually increase in quantity as the years passed and as his constitutional vigor waned, until at last, Haig predicted, "the long pent up store of urates breaks its dams and rushes into the circulation with an overwhelming flood." If not destroyed on the rocks of apoplexy, the helpless victim would be swept onward to heart failure, Bright s disease, or a like fate. (25)... 

Deficiency symptoms in poultry include muscular incoordination, uric acid deposits in the ureters and kidneys and general unthriftiness. Hens receiving insufficient vitamin A produce fewer eggs and the eggs frequently do not hatch. Other deficiency signs in poultry include reduced feed intake, susceptibility to respiratory and other infections and, ultimately, death. 

Diuretics have been shown to have variable effects in relationship to urinary calcium excretion and supersaturation, most notably including loop diuretic induced hypercalciuria and attenuation of urinary calcium excretion by thiazide diuretics. The factors contributing to nephrotoxicity are most commonly associated with multiple factors that favor calcium salt or uric acid deposition at the tubulo-interstitial level. Management of renal stone formation and nephrocalcinosis therefore presents a unique clinical challenge, balancing factors that increase risk for abnormal calcium salt deposition or crystallization, and factors that reduce this risk. 

Caffeine (1,3,7-triniethylxanthine) is the well-known stimnlant present in tea and coffee. Uric acid, the end product of nucleic acid catabolism in humans, birds and reptiles (nric acid was one of the first heterocyclic compounds to be isolated as a pure substance, by the Swedish chemist Carl Scheele in 1776) is formed by the action of the enzyme xanthine oxidase. In cases of excess uric acid, deposition of crystals of uric acid can occur, leading to the joint pain known as gout, usually initially in the big toe and usually in males. 

Except in the case of uricotelic animals, the evolutionary advantage of the conversion of uric acid to ammonia, urea, allantoic acid, or allantoin, is not always clear. The disadvantage of the lack of uricase in man and the higher primates, however, is that the insolubility of uric acid may lead to its deposition in tissues, thereby causing gout. The formation of uric acid deposits in tissues is preceded by and associated with hyperuricemia, the cause of which has been both much studied and hotly debated. It seems... 

The purpose of this paper is to show the preliminary results regarding a red pigment of possible inorganic structure existing in the Uric Acid calculi and responsible for the special type of color of these calculi, however we still ignore its place of origin, exact structure and role played on uric acid deposition and crystallization. 

Patients with chronic Pb nephropathy Severe childhood Pb exposures Uric acid deposits and vascular changes in kidneys Deposits and changes present in the absence of gout and hypertension Inglis et al. (1978)... 

The pink pigment, sometimes seen in urinary uric acid deposits with which it is precipitated. 

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