Ovarian tumors Brenner

Brenner tumors present rare ovarian tumors that occur at a mean age of 50 years. Brenner tumors constitute l%-3% of ovarian tumors. They are mostly henign, with less than 2% demonstrating borderline or malignant transformation. They are typically small, solid, unilateral ovarian tumors, with 60% of these tumors found under 2 cm in size. Extensive calcification may he observed. The vast majority is discovered incidentally in pathologic specimen of the adnexa. Brenner tumors rarely produce estrogen, and then they may be associated with endometrial thickening [87]. If cystic components are found in Brenner tumors, they may be associated with cystadenomas [88]. Up to 20% of Brenner tumors are associated with mucinous cystadenomas or other epithelial neoplasm (Fig. 9.34). 

The typical finding of a Brenner tumors is a small solid tumor that displays very low SI on the T2-weighted images [87]. Dense amorphous calcifications in a small solid ovarian tumor is a typical CT finding. In one series of eight Brenner tumors, the... 

Either benign or malignant ovarian tumors may be associated with virilization. Virilization has been observed in patients with adrenal rest tumors, Leydig cell tumors, granulosa cell tumors, Brenner tumors, and arrhenoblastomas. In patients with hirsutism associated with amenorrhea and sterility, the androstene-... 

Ogawa K, Johansson SL, Gohen SM. Immunohistochemical analysis of utoplakins, urothelial specific proteins, in ovarian Brenner tumors, normal tissues, and benign and neoplastic lesions of the female genital tract. Am JPathol. 1999 155 1047. 

Clear cell carcinoma -Brenner tumor and ovarian transitional cell carcinoma ... 

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