Breast cancer mucinous carcinoma

In another study involving patients with metastatic breast, colorectal and ovarian cancer, increased anti-sTn titers were correlated with better survival. Even if before treatment, elevated titers of antibodies against the mucin MUC1, were correlated with a poor response to immunotherapy, CTL precursors to the MUC1 were detected in carcinoma patients [208], A vaccine using 10 pg/ml MUC1-KLH mixed with Detox was injected s.c. in breast cancer patients treated with cyclophosphamide. A weak antibody response, and an ex vivo CTL response against HLA-matched adenocarcinoma cell lines were seen. No correlation with the clinical outcome was available [209],... 

About 30% of unselected breast carcinomas are associated with HER-2 overexpression most of them are invasive ductal carcinoma, infiammatory breast cancer, Paget s disease as well as breast cancer arising in pregnant women, whereas invasive lobular carcinoma, mucinous carcinoma and medullary carcinoma of the breast are rarely accompanied by HER-2 overexpression. HER-2 overexpression is also found in a significant percentage of male breast carcinomas (about 30%). 

Endometrioid carcinomas represent 8% of all ovarian carcinomas. They occur with synchronous endometrial carcinomas or endometrial hyperplasia in up to 33% of cases [39]. Furthermore, an association with breast cancer has been reported [2]. Rarely, endometrioid carcinoma may arise from endometriosis [40]. Bilateral ovarian involvement is encountered in 30%-50% of cases. Macroscopically, these tumors are solid and cystic, the cysts may contain mucinous or greenish fluid. Rarely, solid tumors with extensive hemorrhage or necrosis may be found [2]. 

CA 125 is a mucin-like glycoprotein antigenic determinant expressed on the surface of coelomic epithelium and human ovarian carcinoma cells however, it does not appear to be specific for ovarian cancer because elevated levels have been reported in breast and colorectal cancers. Studies have shown increased CA 125 levels in patients with ovarian cancer, whereas decreased CA 125 levels in chemotherapy are associated with improved possibility for survival. Some studies have shown failure of CA 125 levels to return to normal after chemotherapy, indicating... 

The three most common special types of invasive cancer are tubular, medullary, and mucinous. Medullary carcinoma is a well-defined lesion with a characteristic microscopic appearance that includes a well-circumscribed border, intense infiltration with small lymphocytes, and other factors. It accounts for 5% to 7% of all breast carcinomas and is believed to have a better prognosis than infiltrat-... 

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