Bottle standard reference material

Hie Standard Reference Material (SRM) is intended primarily for verifying the accuracy used tor the determination of morphine, codeine, cocaine metabolite (benzoylecgonine), marijuana metabolite (THC-9-COOH), and phencyclidine in human urine. SRM 1511 consists of three (3) bottles of freeze-dried urine with all of the analytes in each bottle. 

Statistical control of an analysis or instmment is best demonstrated by SQC of a standard sample analysis. The preferred approach to demonstrate statistical control is to use a reference sample of the subject material that has been carefully analyzed or, alternatively, to use a purchased reference standard. Either material must be stored so that it remains unchanged, eg, sealed in ampuls or septum capped bottles. Periodically a sample can then be reanalyzed by the technique used for routine analysis. These results are plotted in a control chart. Any change in the stabihty of the test in question results in a lack of... 

Moxalactam disodium reference standards are equilibrated under controlled humidity conditions to raise the moisture content to a level where the material can be handled by ordinary means. This is accomplished by spreading a thin layer of material in a wide mouth weighing bottle which is placed in a 42% relative humidity chamber for about 16 hours before use. The 42% relative humidity chamber is prepared by storing a saturated aqueous solution of potassium carbonate in a desiccator or closed chamber held at room temperature. After a 16 hour equilibration period, the water content of the standard is determined by Karl Fischer titration. The activity of the standard is then corrected for the water content of the equilibrated reference material. Experience indicates that the water content of a properly equilibrated reference material should be in the range of 10 to 12%. 

Some refractory elements cannot be determined by ET-AAS at the levels usually present in waters. That is the case with M. El Himri et al. [28] developed a fast and accurate procedure, without any prior treatment, to analyze tap and mineral waters from Spain and Morocco for this highly toxic element. ICP-MS was employed. The analytical isotope selected was 238U, with Rh as internal standard. An LoD of 2ngl 1 was obtained. The estimated repeatability was 3 percent at the concentration level of 73 ng l-1. The method was validated by comparison with a radiochemical procedure devised for natural samples and by analysis of a Certified Reference Material (CRM). Multi-element capabilities of ICP-AES have also been employed for surveys of trace elements. Al-Saleh and Al-Doush [29] reported the concentrations of dissolved Be, Cd, Cr, Cu, Fe, Mg, Mn, Hg, Ni, Se, Sr, V, and Zn in 21 samples of retail bottled waters from Riyadh, Saudi Arabia. It was found that Cd, Fe, Hg, Ni, and Zn were present at concentrations higher than the limits recommended by the EU and World Health Organization (WHO) guidelines. 

Environmental agencies, as well as others studying pollution in the nation s waterways, need materials containing an accurate composition of various compounds as a check to verify the reliability of laboratory instruments and methods. The National Institute of Standards and Technology (NIST) has developed a bottle standard marine reference material (SRM) for this purpose. It contains marine sediment with a wide range of pollutant compounds of interest to environmental scientists. The sediment material, which has certified values of 11 polycyclic aromatic hydrocarbons (PAHS), was collected from the Chesapeake Bay area near Baltimore harbor. It is a dry powder that can be reconstituted into a wet form so that the compounds can be extracted by solvents for organic analysis. See environment. 

In this reaction purified tetrahydrofuran (THF) is required, as well as a standardized solution of Li[AlH4] in tetrahydrofuran. The THF from freshly opened bottles is distilled from Li [A1H4]. ("Caution. Li[AlHJ is a hazardous material and must be handled in dry conditions and in small quantitites. Serious explosions can occur when impure THF is purified if it contains peroxides (see Reference 7). 

Identify all samples being set aside for FDA validation. The samples should include drug substance, drug product, major impurities, and degradation products being controlled for, references standard, and internal standard (the latter is not required if commercially available but is recommended to facilitate FDA laboratory work). If appropriate, blanks and any other materials not commercially available but specified in the analytical procedures should be provided. The samples are to be maintained by the sponsor until the FDA s reviewing chemist provides instructions as to where they should be forwarded. The total quantities and the manner of their subdivision (e.g., 400 tablets, 4 x 100 tablets/ bottle) should be indicated. The amounts provided should be adequate to permit at least three separate determinations, excluding sterility, by two different laboratories. 

In the text the word sample is used in two ways. The sample referred to in Part 1 is the portion of material submitted for chemical analysis, e.g. a 10 mL sample of olive oil removed from a one litre bottle of oil for the purpose of ehemical analysis. When statistieal procedures are applied to the results of analytical measurements (Part 6) the term sample refers to the segment of all the possible results, i.e. the population that is being used to calculate the statistic. Ten measurements are used to calculate the sample standard deviation (see random errors, Section 6.2) the ten results are only a portion of the infinite number of possible measurements. 

The models C-Al-pp and C-Fe-pp were obtained by thoroughly mixing the components in a suspension with a final volume of 1 litre at pH 5.5, and then allowed to react in stoppered polyethylene bottles at 40°C. After ageing 90 days, the materials were dialyzed, air-dried at 40°C, and then ground to pass a 0.25 mm sieve. Reference standards by C and pp with or without Al- or Fe- were also prepared at the same conditions. 

Generally, this clause refers to an international standard, if such exists. If necessary, specific preconditions and methods of sampling or pre-treatment steps for the preservation of the samples (e.g., filtration, acidification, bottle material, storage conditions) are given. 

EYEWASH SHOWER STATIONS Where an employee s eyes or body may be exposed to corrosive materials or chemicals, the employer must provide suitable facilities for quick drenching or flushing of the eyes and body. OSHA does not approve any product, including eyewash stations, but letters of interpretation reference ANSI standard Z358.1, which states the rate of flow at 0.4gpm and the duration of flow to be 15 minutes for portable stations. Portable bottles of eyewash may only be used in the quick treatment of less serious eye and skin irritations. 

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