Bone morphogenetic protein receptor

Suzuki, A, Thies, R S, Yamaji, N, Song, J. J., Wozuey, J. M., Murakami, K., and Ueno, N (1994) A truncated bone morphogenetic protein receptor affects dorsal-ventral patterning m the early Xenopus embryo Proc Natl Acad. Set USA 91, 10,255-10,259... 

Morse, J. H. (2002). Bone morphogenetic protein receptor 2 mutations in pulmonary hypertension. Chest 121, 50S-53S. 

Hay, E., Lemonnier, J., Fromigue, O., Guenou, H., and Marie, P. J. 2004. Bone morphogenetic protein receptor IB signaling mediates apoptosis independently of differentiation in osteoblastic cells. Journal of Biological Chemistry, 279,1650-1658. 

Reynolds, A.M., Xia, W., Holmes, M.D., Hodge, S.J., Danilov, S., Curiel, D.T., Morrell, N.W., and Reynolds, P.N. (2007) Bone morphogenetic protein type 2 receptor gene therapy attenuates hypoxic pulmonary hypertension. Am. J. Physiol. Lung Cell Mol. Physiol. 292, L1182-L1192. 

G5 BMP-12R Brachyury CBF membrane ganglioside related to pericytes identification receptor to bone morphogenetic protein isoform 12 transcription factor related to embryo mesoderm determination core-binding factor protein family involved in cell differentiation... 

Transforming growth factor (3 (TGF(3) (that suppresses cell proliferation), the related develop-mentally important activins (involved in mesoderm induction) and bone morphogenetic proteins (involved in bone formation) act via PM-located transmembrane receptors that are Ser/Thr-specific PKs. Thus, TGF(3 binds to the extracellular domain of a specific TGF(3 receptor with the successive consequences of activation of the receptor Ser/Thr-specific PK activity, phosphorylation of a protein Mad to yield P-Mad and downstream consequences resulting in developmentally important specific gene expression. Thus, dorso-ventral differentiation in Xenopus embryos involves Mad-like proteins and a Mad-like gene is a tumour suppressor gene. 

Fig. 6.5 Signalling through SMAD proteins. Receptor complexes, formed with transforming growth factor.p (TGF-p) and related factors, activins, and bone morphogenetic proteins (BMPs), consist of two serine/threonine receptor kinases, the type II and type I receptors. Binding of the ligand results In autophosphorylation of type I receptors. The activated type I receptors in turn phosphoryiate and activate R-SMADs SMADs 1,...

These receptors have a cysteine-rich extraceUular domain and a cytoplasmic serine/threonine kinase activity.Transforming growth factor-P (TGF-P) superfamily induces growth arrest in epithelial cells. In addition to the three TGF-P isoforms, this family comprises activins, bone morphogenetic proteins and other secreted factors. 

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