Blood group determinant

To study the binding mode of the yS-D-galactopyranosyl residue of the Lewis b human blood-group determinant to its monoclonal antibody or to a lectin, methyl 2-acetamido-2-deoxy-3-0-(6-deoxy-6-fluoro-2-0-a-L-fuco-pyranosyl-y -D-galactopyranosyl)-4-0-a-L-fucopyranosyl-/ -D-glucopyrano-side was synthesized. ... [Pg.221]

Mode of Display of the MN Blood-group Determinants by Glycophorin A. A... [Pg.169]

The results concerning the N-terminal structures of glycophorins A" and A were based on the labels that were placed on the crucial, N-terminal amino group, and they clearly showed that the amino acid residues at position S may play only a minor, if any, role in determining the structure of the MN blood-group determinants. The carbohydrate residues appear... [Pg.194]

The possible role that the lysine residues, N-terminal amino acid residues, and carbohydrate residues may play in the display of the MN blood-group determinants by glycophorins A, A, and has been investigated. Assuming that the N-terminal amino acid in each of these glycoproteins plays a prominent role in the display of the MN blood-group determinant, labels were placed on the N-terminal amino acid residues of the glycoproteins. [Pg.197]

Scheme 2.9 Solid-phase synthesis of an H-type 2 blood group determinant.

SOLID-PHASE SYNTHESIS OF THE LEWISb BLOOD GROUP DETERMINANT... [Pg.28]

The Lewisb blood group determinant (Leb, Fig. 2.1) is another antigen of particular interest. This determinant has been identified as a mediator for the binding of... [Pg.28]

Scheme 2.17 Solid-phase synthesis of a Leb (Lewis 5) blood group determinant.

Figure 14.2 Representative oligosaccharide structures found on mammalian glycoproteins and glycolipids. The complex oligosaccharides may be bi-, tri-, or tetra-antennary the branches may be more or less elongated with 1—>4 linked lactosamine units, and they may or may not be sialylated. The SLex, Lea, and Leb structures represent the different blood group determinants often present on lipids, and the elongated core 2 structure is a mucin-type glycosylation. Proteoglycans have a common core to which a variety of linear acidic polysaccharides are attached.

Other blood-group determinants, such as human P and I, and the J-determinant from cattle, are carbohydrate in nature, but are deficient in, or devoid of, L-fucose, which apparently does not play an immunological role in these antigens.19 ... [Pg.316]

Table XVI. Oligosaccharides Related to Blood-group Determinants. 217...

C-N.m.r. Data56 for Oligosaccharides, Related to Blood-group Determinants, Reduced to Alditols at the Formerly Reducing Residue... [Pg.218]

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