Immunological role

Chelmonska-Soyta, A. 2002. Interferon-tau and its immunological role in ruminant reproduction. Archivum Im-munologiae et Therapiae Experimentalis 50(1), 47-52. 

Other blood-group determinants, such as human P and I, and the J-determinant from cattle, are carbohydrate in nature, but are deficient in, or devoid of, L-fucose, which apparently does not play an immunological role in these antigens.19 ... 

The O-specific polysaccharide components of the lipopolysaccharides of gramnegative bacteria fulfil an immunological role similar to that of the capsular... 

Gallowitsch-Puerta, M., Tracey, K.J. (2005). Immunologic role of the cholinergic anti-inflammatory pathway and the nicotinic acetylcholine alpha 7 receptor. Ann. NY Acad. Sci. 1062 209-19. 

Rauchhaus M, Koloczek V, Volk H, Kemp M, Niebauer J, Francis DP, Coats AJ and Anker SD, Inflammatory cytokines and the possible immunological role for lipoproteins in chronic heart failure. Int J Cardioll6(2-3) 125-33, 2000. 

Such an important biological and immunological role of 3-deoxy ulosonic acids, as well as their unique chemical structure has emerged as an important area of many research fronts. Much attention has been also focused on enzymatic, chemoenzymatic, and stereocontrolled chemical syntheses of all of these compounds and their analogues. 

Andersson DA, Gentry C, Moss S, et al. (2008) Transient receptor potential Al is a sensory receptor for multiple products of oxidative stress. J Neurosci 28 2485-2494 Bang S, Kim KY, Yoo S, et al. (2007) Transient receptor potential Al mediates acetaldehyde-evoked pain sensation. Eur J Neurosci 26 2516-2523 Basu S, Srivastava P (2005) Immunological role of neuronal receptor vanilloid receptor 1 expressed on dendritic cells. Proc Natl Acad Sci USA 102 5120-125 Bautista DM, Jordt SE, Nikai T, et al. (2006) TRPAl mediates the inflammatory actions of environmental irritants and proalgesic agents. CeU 124 1269-1282... 

In 1996 the exosome was discovered to have an immunological function and consequent study of the immunological role of exosomes has been extensive (Raposo et al., 1996). Exosomes have been shown to take part in both T-cell activation (Sprent, 2005) and in tolerance development (Karlsson et al., 2001). It has been shown that exosomes released from mast cells have the capacity to activate T cells and endothelial cells, and in addition to induce DC maturation. Thus, there is now extensive evidence that exosomes can mediate communication between cells over a distance. Furthermore, exosomes primed with specific tumor antigens are under clinical trials for cancer treatment. 

Moncada, S. (1993). The L-arginine nitric oxide pathway, cellular transduction and immunological roles. Adv. Second Messenger Phosphoprotein Res. 28, 97-99. 

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