Blood-group determinants separation

To determine the effects of the test compound on blood gases, heart rate, and arterial blood pressure in separate groups, physiological determinations are performed. To observe the interaction between test compound and anesthesia, the determinations in awake or in anesthetized rats are performed. The ventral tail... 

Partition coefficients of a series of aliphatic hydrocarbons, including n-hexane, have been determined in human tissues (Perbellini et al. 1985). The following partition coefficients for n-hexane (olive oil/air, blood/air, tissue/air) were determined olive oil, 146 blood, 0.80 liver, 5.2 kidney, 3 brain, 5 fat, 104 muscle, 5 heart, 2.8 and lung, 1. Saline/air partition was not reported separately for n-hexane, but was very low for the range reported for the entire group of compounds (0.1-0.4). 

Hydroxypropyl derivatives of cellulose and Sephadex allow further reactions [261] to prepare a wide range of lipophilic ion-exchangers. Because such materials possess relatively high capacity and selectivity toward certain sample types, their further extensive use as group separation media may become popular. Separation of steroid conjugates [262,269], oximated 3-ketosteroids [256], and the metabolites of contraceptive steroid drugs [270] were all achieved with excellent sample recoveries. Such nonadsorptive media are essential in picogram-level determinations of steroids in small samples of blood. 

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