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Blood group determinant oligosaccharide

K.R. Love, P.H. Seeberger, Automated solid-phase synthesis of protected tumor-associated antigen and blood group determinant oligosaccharides, Angew. Chem., Int. Ed. 2004, 43, 602-605. [Pg.688]

Figure 14.2 Representative oligosaccharide structures found on mammalian glycoproteins and glycolipids. The complex oligosaccharides may be bi-, tri-, or tetra-antennary the branches may be more or less elongated with 1—>4 linked lactosamine units, and they may or may not be sialylated. The SLex, Lea, and Leb structures represent the different blood group determinants often present on lipids, and the elongated core 2 structure is a mucin-type glycosylation. Proteoglycans have a common core to which a variety of linear acidic polysaccharides are attached. Figure 14.2 Representative oligosaccharide structures found on mammalian glycoproteins and glycolipids. The complex oligosaccharides may be bi-, tri-, or tetra-antennary the branches may be more or less elongated with 1—>4 linked lactosamine units, and they may or may not be sialylated. The SLex, Lea, and Leb structures represent the different blood group determinants often present on lipids, and the elongated core 2 structure is a mucin-type glycosylation. Proteoglycans have a common core to which a variety of linear acidic polysaccharides are attached.
Table XVI. Oligosaccharides Related to Blood-group Determinants. 217... Table XVI. Oligosaccharides Related to Blood-group Determinants. 217...
C-N.m.r. Data56 for Oligosaccharides, Related to Blood-group Determinants, Reduced to Alditols at the Formerly Reducing Residue... [Pg.218]

Of great importance are the blood group determinants which are discussed in Box 4-C. Tire ABO determinants are found at the nonreducing ends of O-linked oligosaccharides. Conserved Ser/Thr sites in the epidermal growth factor domains (Table 7-3) of various proteins carry O-linked fiicose.235... [Pg.1155]

Oligosaccharides with blood group activity are found in human urine (7) and in human milk (3). Materials with blood group activity are widely distributed in nature (1, 2, 3, 4, 5, 6, 7, 8, 9) as are various proteins, plant (19, 20), and animal hemagglutinins, (21, 22, 23) which show specificity for blood group determinants. [Pg.344]

Lemieux RU, Bock K, Delbaere LTJ, Koto S, Rao VS (1980) The conformations of oligosaccharides related to the ABH and Lewis human blood group determinants. Can J Chem 58 631-653... [Pg.530]

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See also in sourсe #XX -- [ Pg.671 ]



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