Blindness, special considerations

The list of suitable applications also includes a variety of special-purpose systems, especially where high lightfastness and durability, but also high heat stability or other perfect fastness properties are a prime concern. This is true, for instance, for coatings to be applied onto aluminum window blinds. Bilaterally coated, usually in pastel colors, these aluminum strips are baked at 250°C or less and subsequently subjected to considerable mechanical stress. 

In some situations double-blind placebo-controlled trials are not acceptable from an ethical standpoint examples are studies on patients in life-threatening conditions such as severe withdrawal symptoms (e.g. delirium tremens) or diseases with a high risk of suicide. To keep double-blind conditions in longterm treatment may also be difficult or even impossible, e.g. if one of the drugs used needs special safety monitoring or if the side-effect profile requires special treatment considerations. 

First, we do think that future work on Eqs. (1) should take the particular features of the reactor nonlinearity into consideration more than has so far generally been done. Results worked out for more general differential or integral equations should not be blindly applied. Instead one should make more efficient use of the monotonicity and boundedness from below of exp(x) — 1. This may sound trivial but there are far too many papers in reactor dynamics which only try to apply some more general criteria to Eqs. (1) and which do not take the special features of these equations into account. Usually this approach produces overly restrictive results. 

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