Biotechnology products nomenclature

Efforts are under way to make the USP-NF more useful worldwide. Incorporation of monographs for multi-vitamin products, biotechnology-derived products, veterinary drugs, and botanicals and other dietary supplements help. The US AN and USP Dictionary of Drug Names has wide international applicability, thereby making it a repository of International Names Nomenclature (INN) and British Adopted Names (BAN), as well as U.S. Adopted Names (USAN). Pharmacopeial Forum now contains announcements of proposals from the Japanese Pharmacopeia and European Pharmacopeia for revision of standards for international harmonization. 

Scientific data (nomenclature, definition, production, qucdity control during production development chemistry for chemiccil active substances development for the biological/biotechnological active substances development for plant origin active substances impurities batch analyses)... 

The traditional demarcation of the chemistry of natural products from, e.g., the rest of organic chemistry, physics, biosciences and, in particular, biotechnology, molecular biology, and research on active principles is no longer possible. Thus the entire field of the extensively widened topic of natural products chemistry is now often referred to as bioorganic chemistry . The nomenclature principles of natural products - use of semisystematic names - are discussed in Section F of lUPAC rules. The Compendium of lUBMB, Biochemical Nomenclature, London Portland Press 1992, and in the Chemical Abstracts Index Guide. 

The production of PHA using residual oil from biotechnological rhamnose production as a carbon source for growth of C. necator H16 (the nomenclature in the article was "Ralstonia eutropha") andP. oleovorans-was described by Fiichtenbusch et al. (2000). The strains accumulated PHA at 41.3 and 38.9%, respectively, of the cell dry mass when they were cultivated in defined media with oil from the rhamnose production as the sole carbon source. The accumulated PHA isolated from C. necator was identified as PHB homopolyester, whereas the PHA isolated from P. oleovorans consisted, typically for this type of PHA-accumulating organism, of (P)-3-hydroxyhexanoicacid, (P)-3-hydroxyoctanoicacid, (/ )-3-hydroxydecanoic acid and (P)-3-hydroxydodecanoic acid. Approximately 20-25% of the carbon components of the residual oil were converted into PHA. Up to 80% of cell dry mass of PHB homopolyester from different plant oils was produced by C. necator DSM 545 (Fukui and Doi 1998). 

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