12-Hydroxydodecanoic acid

The enzymatic polymerization of 12-hydroxydodecanoic acid in the presence of 11-methacryloylaminoundecanoic acid conveniently produced the methacrylamide-type polyester macromonomer. Lipases CA and CC were active for the macromonomer synthesis. Enzymatic selective monosubstitution of a hydroxy-functional dendrimer was demonstrated. Lipase CA-catalyzed polymerization of 8-CL in the presence of the first generation dendrimer gave the poly(8-CL)-monosubstituted dendrimer. 

Conversion into 12-hydroxydodecanoic acid. The foregoing lactone is added to a solution of potassium hydroxide (150 g) in methanol (800 ml) and the... 

The copolymer of 12-hydroxydodecanoic acid/P-butyrolactone was synthesized at 45 °C in toluene, using Porcine pancreatic lipase [29], After 72 h, the molecular weight of the obtained copolymer in 70% yield was M = 1800. Electrospray... 

Hydroxydodecanoic acid [505-95-3] M216.3,m 86-88 , pKEst 4.8. Crystallise the acid from toluene... 

Oxyacids or their esters were polymerized enzymatically to produce the corresponding polyesters. When using lipase CA, hydrophobic oxyacids were polymerized efficiently [75], with degree of polymerization (DP)-values in excess of 100 for the polymerization of l6-hydroxyhexadecanoic acid, 12-hydroxydodecanoic acid, or... 

Porcine pancreas lipase (PPL) pol5mierized 3-hydroxybutyric and 12-hydroxydodecanoic acids in anhydrons hydrophobic solvents (79). The molecular weight of the polymer from the former was low (ca 500), whereas the polymerization of the latter at 75°C prodnced the polymer with molecnlar weight of 3x10 . A cellulase-assisted pol5mierization of chiral flnorinated compound having carboxylic acid and phenolic groups produced the aromatic polyester (72). 

Enzymatic synthesis of a methacrylamide-type polyester macromonomer was reported (80,81). In the polymerization of 12-hydroxydodecanoic acid in the presence of 11-methacryloylaminoundecanoic acid using lipase CC or Candida antarctica lipase (lipase CA) as catalyst, the polymerizable group was quantitatively incorporated into terminal of the poljmier chain. 

Polyesterifications of various diacids/diols and linear hydroxy acids were studied using lipase-catalysis. The different diols studied include 1,4-butaiw, 1,6-hexane, and 1,8-octane diol. The diacids studied include succinic, glutaric, adipic, and sebacic acid. The different hydroxy acids studied were 6-hydroxyhexanoic acid, 10-hydroxydecanoic acid, 12-hydroxydodecanoic acid, and 16-hydroxyhexadecanoic. The effect of the chain length of the diol and diacids and hydroxy acids on the build-up of polymer chains by lipase-catalyzed polycondensation reactions was studied. The effect of reaction parameters on product molecular weight averages and chain dispersity were assessed. 

Lipase CA also polymerized hydrophobic oxyacids efficiently [88]. The DP value was beyond 100 in the polymerization of l6-hydroxyhexadecanoic acid, 12-hydroxydodecanoic acid, or 10-hydroxydecanoic acid under vacuum at high temperature (90 °C) for 24 h, whereas a polyester with a lower molecular weight was formed from 6-hydroxyhexanoic acid under similar reaction conditions. This difference may be due to the lipase-substrate interaction. Similar behaviors were reported in the lipase-catalyzed ring-opening polymerization of lactones in different ring sizes [24,25]. 

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