Bioresorbable polymers biomaterials

Biomass Research and Development Initiative iolnitiative), 24 192 Biomaterial coatings, ethylene oxide polymers in, 70 688 Biomaterials, 3 707-709. See also Biomaterials, prosthetics, and biomedical devices bioresorbable polymers, 3 735-740... 

Vert, M., Christel, P., Chabot, F., Leray, J., 1984. Bioresorbable polymers for bone surgery. In Hastings, G.W., Ducheyne, P. (Eds.), Macromolecular Biomaterials. CRC Press, Boca Raton, pp. 119—142. 

The bioresorbable polymers in medicine represent a diverse family within the field of biomaterials. To understand properly aU the science behind these attractive materials, it is necessary to start with general definitions. 

Various copolymers with a high PDO content have been synthesized and studied to improve the mechanical performance and increase the rate of resorption [40]. A copolymer with 80 % PDO and up to 20 % PGA has a resorption profile similar to Dexon and Vicryl and yet maintains a compliance similar to PDS . The copolymer with 85 % PDO and up to 15 % PLLA exhibits higher compliance and a lower modulus than the PDO homopolymer, yet its resorption profile is similar to PDS [41]. Copolymers with three or more different monomer units have also been explored. One such example is poly(GA-co-PDO-co-LA), which has been proposed as a possible suture material with suitable crystallinity, good flexibility, better strength retention, and a reasonably rapid resorption rate [42]. Until recently, there was not much interest in developing PDO as a biomaterial, mainly because of the lack of commercial availability and difficulties in its synthesis. However, with the development of new alternative synthesis procedures and the availability of the PDO monomer, there has been more commercial interest in developing PDO as a bioresorbable polymer in recent years (Table 4.6). 

This review focuses on those synthetic bioresorbable polymers that can be spun into fibers or filaments, and subsequently used as biotextiles. We have listed and reported on the properties and applications of both conventional and commercially available fiber-forming bioresorbable polymers as well as those that are still being developed experimentally. Factors affecting the performance of these biomaterials are presented and the precautionary measures that may be taken to reduce the hydrolytic degradation during manufacturing and processing are discussed. 

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Li, S. and Vert, M., Hydrolytic degradation of coral/poly(DL-lactic acid) bioresorbable material. Journal of Biomaterials Science - Polymer Edition 7, 817-827 (1996). 

Shen, X., Su, F., Dong, J., Fan, Z., Duan, Y., Li, S., 2015. In vitro biocompatibility evaluation of bioresorbable copolymers prepared from L-lactide, 1, 3-trimethylene carbonate, and gly-cobde for cardiovascular appbcations. Journal of Biomaterials Science Polymer Edition 26, 497-514. 

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