Bioprocess Expert

POWERTRAN-PC, from Bigelow Systems DataLogiX, from DataLogiX Formula Systems G2, a bioprocess expert program with simulation and control from GENSYM, Cambridge, MA... 

An expert system is a computer program to reproduce a problem-solving manner according to an expert s knowledge and inference procedures in a computer system. Expert systems have been used for fault diagnosis in bioprocess operations, the improvement of medium composition, and the optimization of culture conditions, since it can handle a large amount of information and data concerning bioprocess operation and optimization [13]. 

The undelayed evaluation of state of a culture by using software sensors and computers, based on the quantitative analytical information provided by hardware sensors and intelligent analytical subsystems, constitutes an excellent basis for targeted process control. Experts - either human or computer - have the data and the deterministic knowledge to trace observed behavior back to the physical, chemical and physiological roots thereby gaining a qualitative improvement of bioprocess control, a quantum leap process control can act on the causes of effects rather than just cure symptoms. A simple standard operating procedure [398] has proven useful, namely ... 

Cimander C, Bachinger T, Mandenius CP. Integration of distributed multi-analyzer monitoring and control in bioprocessing based on a real-time expert system. J Biotechnol 2003, 15 Aug 103(3) 237-248. 

The industrial use of bio catalysts has been reviewed in many excellent papers from industrial and academic experts in recent years [6-20]. These publications clearly show that immobilized systems find only limited use in present bioprocesses. Straathof et al. recently investigated 134 industrial biotransformations and came to the conclusion that only 20 confirmed processes rely on immobilized bio catalysts [15]. This is due to the fact that immobilization can be a considerable cost factor and is frequently used in combination with less common continuous reactors. In addition, many transformations belong to the class of redox reactions and require a cofactor for the reaction to occur. Such processes can in many cases be realized perfectly under fermentative conditions by the use of living or resting cells [17,21-25]. 

Hitzmann, B., Gomersall, R., Brandt, J., van Putten, A. (1995) An expert system for the supervision of a multi channel flow injection analysis system. In Recent Advances in Biosensors, Bioprocess Monitoring, and Bioprocess Control, K.R. Rogers, A. Mulchandani, W. Zhou, Eds., ACS Symposium Series, American Chemical Society, Washington, D.C. (this vol.)... 

Chapters 9-16 cover the application of optical and biosensor methods for on-line monitoring and control of bioprocesses. Topics include the use of expert systems for controlling flow injection analysis systems and hybrid process modeling for bioprocess control. 

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