Synthetic biological response modifiers

Natural and Synthetic Biological Response Modifiers (BRMs).159... 

NATURAL AND SYNTHETIC BIOLOGICAL RESPONSE MODIFIERS (BRMs)... 

Finally, biological response modifiers should be mentioned. Immunostimulants, a concept predating this century, are making a modern-day comeback with intensive research of interferons, interleukin, and synthetic polynucleotides. Studies involving interleukin-2 described significant responses in patients with melanoma, colorectal, kidney, and lung cancers. This and other stimulant factors are now in clinical use (see Chapter 15). 

Several natural dietary supplements are commonly accepted to benefit the immune system, i.e., act as biological response modifiers that stimulate nonspecific immunity. Among these are various synthetic and biological agents, each with completely different chemical stractures. Herbs such as... 

Interleukin-12 (IL-12) is one of a group of the related proteins made by leukocytes (white blood cells) and other cells in the body. Interleukin-12 (IL-12) is made mainly by B lymphocytes and macrophages. Interleukin-12 (IL-12) causes other immune cells to make cytokines and increases the growth of T lymphocytes. Interleukin-12 (IL-12) may also block the growth of new blood vessels. A synthetic interleukin-12 (IL-12) is used as a biological response modifier to boost the immune system in cancer chemotherapy. Interleukin-12 (IL-12) is a type of cytokine of the factor which regulates the cell proliferation differentiation. 

Synthetic polymers make up by far the broadest and most diverse class of biomaterials This is mainly because synthetic polymers are available with such a wide variety of compositions and properties and also because they may be fabricated readily into complex shapes and structures. In addition, their surfaces may be readily modified physically, chemically, or biochemically. Such modifications can have significant influences on biologic responses to the biomaterials. When a foreign biomaterial contacts blood or tissue fluids, the first measurable response in the initial seconds to... 

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