Biodegradable polyurethanes nanoparticle

Ou C, Su C, Jeng U, Hsu S. Characterization of biodegradable polyurethane nanoparticles and thermally induced self-assembly in water dispersion. Acs Appl Mater Interfaces April 23, 2014 6(8) 5685-94. 

Chen YP, Hsu SH. Preparation and characterization of novel water-based biodegradable polyurethane nanoparticles encapsulating superparamagnetic iron oxide and hydrophobic drugs. J Mater Chem B 2014 2 3391 01. 

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Other Synthetic Biodegradable Polymers Although well investigated for drug delivery, polyorthoesters, polyurethanes, and polyamides have found limited application as nanoparticles. A report documents the synthesis and characterization of polyorthoester nanoparticles [105],... 

Korayem AH, Barati MR, Simon GP, Zhao XL, Duan WH (2014) Relrrforcing brittle and ductile epoxy matrices using carbon nanombes mastmbatch. Compos A Appl Sci Manuf 61 126-133 Kotchey GP, Zhao Y, Kagan VE, Star A (2013) Peroxidase-mediated biodegradation of carbon nanombes in vitro and in vivo. Adv Dmg Deliv Rev 65(15) 1921-1932 Krause RWM, Mamba BB, Dlamini LN, Durbach SH (2010) Fe-Ni nanoparticles supported on carbon nanombe-co-cyclodextrin polyurethanes fm the removal of trichloroethylene in watra-. J Nanopart Res 12(2) 449-456... 

The most widely used reinforcements in nanocomposites are carbon nanotubes, layered clay, and nanoparticles. The most widely used polymer matrices are polyamides, nonpolar polymers, polyesters, epoxies, and polyurethane. However, this chapter will focus on nanocomposites which are made from both biodegradable fiber/fillers and biodegradable matrices, since only these composites truly justify the definition of eco-friendly and green nanocomposites. 

There are many polymers that are suitable for the production of nanoparticles employed for drug delivery, which can generally be divided into two groups natural polymers, e.g., polysaccharides (chitosan), proteins (albumin, gelatin), as well as synthetic polymers, e.g., polyesters (poly(lactic add), poly(glycolic add), poly(hydroxy butyrate), poly-e-caprolactone, poly-p-malic add, poly(dioxanones)) polyanhydrides (poly(adipic add)) polyamides (poly(amino acids)) phosphorous-based polymers (polyphosphate) poly(cyano acrylates) polyurethanes polyortho esters and polyacetals. Extreme attention has to be paid to the biodegradability and biocompatibility of the polymers. It is essential that polymers used for medical applications are not detrimental for the tissue or cells and that they can be easily decomposed into simple harmless molecules and eliminated by the human body [ 18-22]. 

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